Published January 2014
| Version v1
Journal article
Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice
- Others:
- Institut cellule souche et cerveau (U846 Inserm - UCBL1) ; Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Institut de pharmacologie moléculaire et cellulaire (IPMC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)
- Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN) ; Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Neurobiologie intégrative et adaptative (NIA) ; Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS)
Description
Psychostimulants such as amphetamine and methylphenidate, which target the dopamine transporter (DAT), are the most frequently used drugs for the treatment of hyperactivity and cognitive deficits in humans with attention deficit hyperactivity disorder (ADHD). While psychostimulants can increase activity in healthy subjects, they exert a "paradoxical" calming effect in humans with ADHD as well as in hyperactive mice lacking the dopamine transporter (DAT-KO mice). However, the mechanism of action of these drugs and their impact on cognition in the absence of DAT remain poorly understood.
Abstract
International audience
Additional details
- URL
- https://hal-amu.archives-ouvertes.fr/hal-01770083
- URN
- urn:oai:HAL:hal-01770083v1
- Origin repository
- UNICA