Published 2022
| Version v1
Publication
Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment
- Creators
- Bertoni, Arinna
- Penco, Federica
- Mollica, Hilaria
- Bocca, Paola
- Prigione, Ignazia
- Corcione, Anna
- Cangelosi, Davide
- Schena, Francesca
- Del Zotto, Genny
- Amaro, Adriana
- Paladino, Noemi
- Pontali, Emanuele
- Feasi, Marcello
- Signa, Sara
- Bustaffa, Marta
- Caorsi, Roberta
- Palmeri, Serena
- Contini, Paola
- De Palma, Raffaele
- Pfeffer, Ulrich
- Uva, Paolo
- Rubartelli, Anna
- Gattorno, Marco
- Volpi, Stefano
- Others:
- Bertoni, Arinna
- Penco, Federica
- Mollica, Hilaria
- Bocca, Paola
- Prigione, Ignazia
- Corcione, Anna
- Cangelosi, Davide
- Schena, Francesca
- Del Zotto, Genny
- Amaro, Adriana
- Paladino, Noemi
- Pontali, Emanuele
- Feasi, Marcello
- Signa, Sara
- Bustaffa, Marta
- Caorsi, Roberta
- Palmeri, Serena
- Contini, Paola
- De Palma, Raffaele
- Pfeffer, Ulrich
- Uva, Paolo
- Rubartelli, Anna
- Gattorno, Marco
- Volpi, Stefano
Description
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in a severe pneumonia associated with elevation of blood inflammatory parameters, reminiscent of cytokine storm syndrome. Steroidal anti-inflammatory therapies have shown efficacy in reducing mortality in critically ill patients; however, the mechanisms by which SARS-CoV-2 triggers such an extensive inflammation remain unexplained.
Additional details
- URL
- https://hdl.handle.net/11567/1099238
- URN
- urn:oai:iris.unige.it:11567/1099238
- Origin repository
- UNIGE