Two new eudesman-4a-ol epoxides from thestem essential oil of Laggera pterodontafrom C^ote d'Ivoire

Description

The investigation of the stem essential oil of Laggera pterodonta(DC.) Sch. Bip. ex Oliv. (Asteraceae) from C^ote d'Ivoire was carriedout, using a combination of chromatographic (GC-RI, CC, pc-GC)and spectroscopic (GC-MS, 13C NMR) techniques. This study led tothe identification of fifty constituents of which two new naturalcompounds 7b,11b-epoxy-eudesman-4a-ol and 7a,11a-epoxyeudesman-4a-ol. Their structures were elucidated by 1D and 2DNMR spectroscopy after pc-GC purifying. Finally, 98.9% of thewhole composition of the oil was identified with a high amountof 2,5-dimethoxy-p-cymene (78.9%). The other significant componentswere a-humulene (6.2%), (E)-b-caryophyllene (1.7%), thymylmethyl oxide (1.7%), a-phellandrene (1.5%), p-cymene (1.2%),(3aH,4bH,6aH,1aMe)-1,6-epoxy-3-hydroxycarvotanacetone angelicacid ester (1.1%) and 10-epi-c-eudesmol (1.0%).

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