Published May 2009 | Version v1
Journal article Metadata-only

[Regulation of vesicular transport by membrane curvature]

Drin, Guillaume
Bigay, Joelle
Antonny, Bruno
Other:
Institut de pharmacologie moléculaire et cellulaire (IPMC) ; Université Nice Sophia Antipolis (1965 - 2019) (UNS) ; COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)

Description

A cellular membrane is highly deformable: during the last decade, numerous studies have dissected at the molecular scale how during vesicular transport various proteins could deform a membrane or recognize membrane deformation. We will discuss how the activity of ArfGAP1 and GMAP-210, two proteins involved in vesicular transport, is regulated by membrane curvature thanks to an ALPS motif. Since a membrane is not solely defined by its shape but also by its lipids composition, we will show how others proteins are adapted to other lipid compositions to recognize membrane shape.

Abstract

International audience

Additional details

Identifiers Origin repository
Created:
December 4, 2022
Modified:
November 30, 2023