AIEZZA N.

Last name: AIEZZA N.

2021 (v1)

Publication

Metadata-only

KPC-53, a KPC-3 variant of clinical origin associated with reduced susceptibility to ceftazidime-avibactam

Di Pilato V. Aiezza N. Viaggi V.

This study reports on the characterization of a Klebsiella pneumoniae clinical isolate showing high-level resistance to ceftazidime-avibactam associated with the production of KPC-53, a KPC-3 variant exhibiting a Leu167Glu168 duplication in the Ω-loop and a loss of carbapenemase activity. Whole-genome sequencing (WGS) revealed the presence of...

Uploaded on: April 14, 2023
2022 (v1)

Publication

Metadata-only

Resistome and virulome accretion in an NDM-1-producing ST147 sublineage of Klebsiella pneumoniae associated with an outbreak in Tuscany, Italy: a genotypic and phenotypic characterisation

Di Pilato V. Henrici De Angelis L. Aiezza N.

Background: Carbapenemase-producing Enterobacterales (CPE), particularly those producing metallo-β-lactamases, are among the most challenging antibiotic-resistant pathogens, causing outbreaks of difficult-to-treat nosocomial infections worldwide. Since November 2018, an outbreak of New Delhi metallo-β-lactamases-positive CPE (NDM-CPE) has...

Uploaded on: April 14, 2023
2020 (v1)

Publication

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Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-β-lactamase-producing enterobacterales during a regional outbreak

Falcone M. Tiseo G. Antonelli A.

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may...

Uploaded on: April 14, 2023

AIEZZA N.

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