ALBERCA MANZANO , Saúl

El objetivo principal de esta Tesis Doctoral se ha centrado en el desarrollo de estrategias sintéticas basadas en el empleo de hidrazonas como reactivos, en combinación con métodos de activación organocatalíticos (aminocatálisis) o por catálisis de Pd(II). Además, en este último contexto las hidrazonas tienen un papel esencial como ligandos...

Catalysts generated by combinations of Pd(TFA)2and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding a-aryl a-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building...

Catalysts generated by combinations of Pd(TFA)2 and pyridine-hydrazone ligands have been applied to 1,2 addition of arylboronic acids to aliphatic N-carbamoyl (Cbz) hydrazones, affording protected α- aryl monoalkylhydrazines with high enantioselectivities (37-99% ee). Subsequent removal of the benzyloxy carbonyl protecting group provides a...