ANNA MARIA SCHITO

Difficult-to-treat bacterial infections involving resistant human and plant pathogens, severely afflict hospitals and concern the agri-food sector. Bacteria of the genus Pseudomonas can quickly become resistant to antibiotics and spread such resistance to other bacteria. Species such as P. aeruginosa, P. putida and P. fluorescens, which...

The global emerging infectious diseases caused by multi-drug resistant (MDR) bacteria necessitates worldwide systematic efforts to discover new effective antibacterial agents, replacing traditional antibiotics no longer active. For this purpose, we recently synthetized amino acid-modified cationic dendrimers and ammonium hydrochloride...

No description

Urinary tract infections are often polymicrobial and are mainly due to uropathogenic Escherichia coli (UPEC). We previously demonstrated a link among clinical fluoroquinolone susceptible E. coli reducing in vitro urothelial interleukin-8 (CXCL8) induced by E. coli K-12, polymicrobial cystitis, and pyuria absence. Here, we evaluated whether...

Molecules containing the pyrazole nucleus are widely reported as promising candidates to develop new antimicrobial compounds against multidrug resistant (MDR) bacteria no longer inhibited by available antibiotics. Recently, aiming at improving the too high minimum inhibitory concentrations (MICs) of a pyrazole hydrochloride salt (CB1H),...

Here, a new two-component hydrogel (CP1OP2-Hgel) was developed, simply by dispersing in water two cationic bactericidal polymers (CP1 and OP2) effective against several multidrug-resistant (MDR) clinical isolates of the most relevant Gram-positive and Gram-negative species. Interestingly, while OP2 acts only as an antibacterial ingredient when...

Low-molecular-weight organic ammonium salts exert excellent antimicrobial effects by interacting lethally with bacterial membranes. Unfortunately, short-term functionality and high toxicity limit their clinical application. On the contrary, the equivalent macromolecular ammonium salts, derived from the polymerization of monomeric ammonium...

During our research on plant compounds from Salvia species able to face the constantly increasing resistance to antibiotics (1), the antimicrobial properties of the dichloromethane extract obtained from the surface of the aerial parts of S. tingitana were investigated following a bioassay-oriented fractionation approach. The surface extract...

Introduction: Gallic acid (GA) is a natural polyphenol endowed with remarkable antioxidant potency and with strong potentials for preventing oxidative degradation in foods and essential oils (EOs), treating diseases triggered by accumulation of radical oxygen species (ROS), oxidative stress (OS) or by antibiotic-resistant infections....