BALANSKY , Roumen

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Cigarette smoke (CS) and ethanol (EtOH) are known to synergize in the causation of cancers of the upper aerodigestive tract and of the liver. Little is known about possible interactions between these agents in other organs. These premises prompted us to evaluate the clastogenic effects resulting from the inhalation for 3 weeks of mainstream CS...

Many drugs in common use possess pleiotropic properties that make them capable of interfering with carcinogenesis mechanisms. We discuss here the ability of pharmacological agents to mitigate the pulmonary carcinogenicity of mainstream cigarette smoke. The evaluated agents include anti-inflammatory drugs (budesonide, celecoxib, aspirin,...

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The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in smoke-related lung carcinogenesis is still controversial. We have developed and validated a murine model for evaluating the tumorigenicity of mainstream cigarette smoke (MCS) and its modulation by chemopreventive agents. In the present study, the protective effects of the nonselective...

Chronic inflammation plays a crucial role in cigarette smoke-related carcinogenesis. Accordingly, anti-inflammatory agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), provide a rational strategy in cancer chemoprevention. We assayed celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and licofelone, an inhibitor of COX-1,...

Lapatinib, a dual tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2), is prescribed for the treatment of patients with metastatic breast cancer overexpressing HER-2. Involvement of this drug in pulmonary carcinogenesis has been poorly investigated. We used murine...

Chemoprevention provides an important strategy for cancer control in passive smokers. Due to the crucial role played by smoke-related chronic inflammation in lung carcinogenesis, of special interest are extensively used pharmacological agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs). We evaluated the ability of aspirin and...

La chemioprevenzione rappresenta un'importante strategia di controllo del cancro polmonare nei fumatori passivi. Di particolare interesse sono i farmaci antinfiammatori non steroidei (FANS), a causa del ruolo cruciale dell'infiammazione cronica indotta dal fumo nella cancerogenesi del polmone. Nel presente studio abbiamo valutato la capacità di...

Assessing the correlation between molecular endpoints and cancer induction or prevention aims at validating the use of intermediate biomarkers. We previously developed murine models that are suitable to detect both the carcinogenicity of mainstream cigarette smoke (MCS) and the induction of molecular alterations. In this study, we used 931...

The anti-diabetic drug metformin is endowed with anti-cancer properties. Epidemiological and experimental studies, however, did not provide univocal results regarding its role in pulmonary carcinogenesis. We used Swiss H mice of both genders in order to detect early molecular alterations and tumors induced by mainstream cigarette smoke. Based...

INTRODUZIONE: La metformina è il farmaco più usato nel mondo per il trattamento del diabete di tipo 2. Vi sono indizi che questo farmaco abbia anche proprietà anticancerogene, ma gli studi epidemiologici e sperimentali non ne hanno chiarito il ruolo in cancerogenesi polmonare. MATERIALI E METODI: Abbiamo usato topi Swiss H di entrambi i generi...

La metformina è un biguanide ipoglicemizzante ampiamente utilizzato per il trattamento del diabete di tipo 2. Negli ultimi anni, un'attenzione crescente nei confronti di questo farmaco è legata alla possibilità che la metformina possa anche agire come un farmaco antitumorale e possa quindi essere proposta come potenziale agente...