BENHIDA , Rachid

Various techniques have been used to "clean-up" wet-process phosphoric acid such as precipitation, flotation and adsorption. To address the potential of membrane processes in the phosphoric acid clarification process, this study explores the benefits of membrane techniques as a green separation technique for phosphoric acid clarification in an...

International audience

International audience

International audience

International audience

International audience

Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy. This class of compounds has found broad applications such as reaction catalysts, organic strong bases, ligands for metal complexation, or versatile starting materials in...

Fluosilicic acid is a by-product of the chemical phosphate industry, mainly during the manufacture of phosphoric acid and triple super phosphate (TSP). To ensure the accurate measurement of the H2SiF6 mass fraction in this by-product, method validation is required, which needs a certified reference material (CRM) with its traceability to the...

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In this study we describe the development of new lipophilic and biocompatible benzothiazole-based push-pull fluorophores as potent fluorogenic probes for the specific staining of intracellular lipid droplets (LDs) at ultralow concentration (≤ 100 nM). These new fluorophores, harboring a D-π-A framework featuring an extended π-conjugated spacer,...

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We report the synthesis of two new artificial nucleobase scaffolds, 1 and 2, featuring adequate hydrogen bonding donors and acceptors for the molecular recognition of U:A and C:G base pairs, respectively. The tethering of these structures to various amino acids and the assessment of these artificial nucleobase-amino acid conjugates as RNA...

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DNA inevitably undergoes a high number of damages throughout the cell cycle. To preserve the integrity of the genome, cells have developed a complex enzymatic machinery aimed at sensing and repairing DNA lesions, pausing the cell cycle to provide more time to repair, or induce apoptosis if damages are too severe. This so-called DNA-damage...

In cancers, hypoxia inducible factor 1 (HIF-1) is an over-expressed transcription factor, which regulates a large set of genes involved in tumour vascularization, metastases, and cancer stem cells (CSCs) formation and self-renewal. This protein has been identified as a relevant target in oncology and several HIF-1 modulators are now marketed or...

Selective imaging of cellular organelles is a rapidly expanding field of research. Within this context we describe the development of two novel profluorescent probes, MitoP-2 and MitoP-3, for the precise staining of mitochondrial compartments. Herein, we demonstrate that caged, non-fluorescent styryl-benzothiazole probes harbouring a...

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We report the development of four novel fluorescent probes to monitor the activity of the β-galactosidase enzyme (β-gal), in vitro and in living cells. The fluorophores are based on a 6-amino-styryl-benzothiazole push-pull core and display a strong ICT emission. The probes encompass the fluorescent motif that is connected to a...

Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African...

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