Stroke is the third leading cause of death, due to its high incidence, theseverity of the insult, and lack of treatment options. The only therapeutic is restoration ofcerebral blood flow achieved by recombinant tissue plasminogen activator treatment,but only approximately 5% of patients receive it. In addition, therapeutics aimed atachieving...
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2011 (v1)Journal articleUploaded on: December 4, 2022
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January 2016 (v1)Journal article
Stroke is a worldwide major cause of mortality and morbidity. Preclinical studies have identified over 1000 molecules with brain-protective properties. More than 200 clinical trials have evaluated neuroprotective candidates for ischemic stroke yet, to date almost all failed, leading to a re-analysis of treatment strategies against stroke. An...
Uploaded on: December 4, 2022 -
June 2021 (v1)Journal article
No abstract available
Uploaded on: December 4, 2022 -
June 22, 2018 (v1)Journal article
International audience
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January 2005 (v1)Journal article
The nutritional interest of polyunsaturated fatty acids from omega-3, that are mainly present in vegetal and fish oils is now validated by the scientific community. Their beneficial effects have first been reported in coronary heart diseases. Many neurological and chronic diseases are often related to deficiencies in omega-3 and omega-6 and...
Uploaded on: December 4, 2022 -
2004 (v1)Journal article
Ischemia and seizures are common diseases that result in neuronal death. To-date, there are no available treatments to block or reverse neuronal death pathways in patients who suffer from these diseases. All drugs that have been shown to be neuroprotective in animal models have failed in human trials. Therefore, the potential of preventative...
Uploaded on: December 4, 2022 -
2006 (v1)Journal article
Linoleic acid, precursor of omega-6, and alpha-linolenic acid, precursor of omega-3, undergo several transformations to form, respectively,arachidonic acid and eicosapentaenoic and docohexaenoic acids. A ratio of 5/1 between linoleic and alpha-linolenic acids intake is recommended.However, the dietary intake of the French population is far from...
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July 18, 2017 (v1)Journal article
Brief periods of ischemia have been shown in many experimental setups to provide tolerance against ischemia in multiple organs including the brain, when administered before (preconditioning) or even after (postconditioning) the normally lethal ischemia. In addition to these so-called ischemic conditionings, many pharmacological and natural...
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September 2016 (v1)Journal article
International audience
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2004 (v1)Journal article
The sphingolipid sphingosine-1-phosphate (S1P) acts on five subtypes of G protein coupled receptors,termed S1P1 (formerly Endothelial Differentiation Gene-1, Edg-1), S1P2 (Edg-5), S1P3 (Edg-3), S1P4(Edg-6) and S1P5 (edg-8), and possibly several other "orphan" receptors, such as GPR3, GPR6 andGPR12. These receptors are coupled to different...
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May 2010 (v1)Journal article
Sixty-seven million pounds of horsemeat derived from American horses were sent abroad for human consumption last year. Horses are not raised as food animals in the United States, and mechanisms to ensure the removal of horses treated with banned substances from the food chain are inadequate at best. Phenylbutazone (PBZ) is the most commonly...
Uploaded on: December 3, 2022 -
February 2019 (v1)Journal article
One of the biggest challenges in medicine is to dampen the pathophysiological stress induced by an episode of ischemia. Such stress, due to various pathological or clinical situations, follows a restriction in blood and oxygen supply to tissue, causing a shortage of oxygen and nutrients that are required for cellular metabolism. Ischemia can...
Uploaded on: December 4, 2022 -
October 3, 2019 (v1)Journal article
Cruise tourism to Antarctica is constantly growing. Passengers and crewmembers may experience illnesses or injuries while traveling to remote areas with harsh weather conditions from where prompt evacuation is mostly unavailable. While a small explorer ship was at Wilhelmina bay (64°39' South and 62°08' West) in the Antarctic Peninsula, a...
Uploaded on: December 4, 2022 -
2001 (v1)Journal article
The transcription factor nuclear factor-κB (NFκB) is an ubiquitously expressed inducible regulator of a broad range of genes and plays a pivotal role in cell death and survival pathways. Three models of brain tolerance (ischemic, epileptic, and polyunsaturated fatty acid-induced preconditioning), known to confer resistance to neurons against...
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August 31, 2016 (v1)Journal article
International audience
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July 2020 (v1)Journal article
In eukaryotes, the polyamine pathway generates spermidine that activates the hypusination of the translation factor eukaryotic initiation factor 5A (eIF5A). Hypusinated-eIF5A modulates translation, elongation, termination and mitochondrial function. Evidence in model organisms like drosophila suggests that targeting polyamines synthesis might...
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September 5, 2019 (v1)Journal article
Diabetes affects more than 425 million people worldwide, a scale approaching pandemic proportion. Diabetes represents a major risk factor for stroke, and therefore is actively addressed for stroke prevention. However, how diabetes affects stroke severity has not yet been extensively considered, which is surprising given the evident but...
Uploaded on: December 4, 2022 -
2016 (v1)Journal article
Lysophospholipids (LPLs) are important interme-diates in the synthesis and degradation of membrane phospho-lipids. Here we show that certain LPLs, particularly lysophos-phatidylcholine and lysophosphatidylinositol, prevent neuronal death both in an in vivo model of transient global ischemia and in an in vitro model of excitotoxicity using...
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January 2013 (v1)Journal article
Stroke is a worldwide main cause of mortality and morbidity. Most of the preventive and neuroprotective treatments identified in preclinical studies failed in clinical trials. Although there is a consensus that nutrition is important for health, its role is underestimated in stroke. Indeed an increase consumption of salt and fatty foods may...
Uploaded on: December 4, 2022 -
September 2015 (v1)Journal article
Inflammation is an innate mechanism that defends organisms against harmful stimuli. Inflammation leads to the production and secretion of proinflammatory mediators that activate and recruit immune cells to damaged tissues, including the brain, to resolve the cause of inflammation. In the central nervous system, inflammation is referred to as...
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January 2013 (v1)Journal article
International audience
Uploaded on: December 4, 2022 -
January 2013 (v1)Journal article
International audience
Uploaded on: February 23, 2023 -
June 2016 (v1)Journal article
International audience
Uploaded on: December 4, 2022