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BOTTLAENDER , Michel

Last name: BOTTLAENDER

First name: Michel

February 20, 2024 (v1)

Publication

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Generating PET-derived maps of myelin content from clinical MRI using curricular discriminator training in generative adversarial networks

Soulier, Théodore Hamzaoui, Mariem Sales Pitombeira, Milena

Multiple sclerosis (MS) is a demyenalinating inflammatory neurological disease. In vivo biomarkers of myelin content are of major importance for patient care and clinical trials. Positron Emission Tomography (PET) with Pittsburgh Compound B (PiB) provides a specific myelin marker. However, it is not available in clinical routine. In this paper,...

Uploaded on: December 29, 2023
December 2023 (v1)

Journal article

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Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer's disease patients are associated with cognitive impairment

Xicota, Laura Lagarde, Julien Eysert, Fanny

Abstract Morphological alterations of the endosomal compartment have been widely described in post-mortem brains from Alzheimer's disease (AD) patients and subjects with Down syndrome (DS) who are at high risk for AD. Immunostaining with antibodies against endosomal markers such as Early Endosome Antigen 1 (EEA1) revealed increased size of...

Uploaded on: February 28, 2023