C

CARDINALI B

Last name: CARDINALI B

2014 (v1)

Publication

Metadata-only

Lapatinib concentration in cerebrospinal fluid in two patients with HER2-positive metastatic breast cancer and brain metastases

Gori S Lunardi G Inno A

Lapatinib is able to penetrate brain metastases from HER2-positive breast cancer. We assessed lapatinib concentration in cerebrospinal fluid (CSF) of two patients with HER2-positive metastatic breast cancer and brain metastases, and we found low levels of the drug in CSF of both patients. Lapatinib concentration in CSF may not be a reliable...

Uploaded on: April 14, 2023
2015 (v1)

Publication

Metadata-only

Analysis of in vitro ADCC and clinical response to trastuzumab: possible relevance of Fc gamma RIIIA/Fc gamma RIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines

Boero S Morabito A Banelli B

Background: Trastuzumab is a humanized monoclonal antibody (mAb) currently used for the treatment of breast cancer (BC) patients with HER-2 overexpressing tumor subtype. Previous data reported the involvement of Fc gamma RIIIA/IIA gene polymorphisms and/or antibody-dependent cellular cytotoxicity (ADCC) in the therapeutic efficacy of...

Uploaded on: April 14, 2023