CASETTA , Ilaria

BACKGROUND: Acute ischemic stroke (AIS) triggers both systemic and neurovascular inflammation, influencing post-stroke recovery. In smokers with AIS inflammation might be further upregulated, increasing ischemia/reperfusion injury. Here, the predictive value of leukocyte and adhesion molecules levels on post-stroke outcomes was investigated....

BACKGROUND: Soluble mediators have been investigated to predict the prognosis of acute ischemic stroke (AIS). Among them, proprotein convertase subtilisin/kexin type 9 (PCSK9) might have both clinical and pathophysiological relevance. MATERIALS AND METHODS: All available serum samples from a cohort of patients with first AIS (n=72) were tested...

Background: we aimed to characterize the temporal evolution and prognostic significance of perihematomal perfusion in acute intracerebral hemorrhage (ICH). Methods: single center prospective cohort of patients with primary spontaneous ICH receiving computed tomography perfusion (CTP) within 6 h from onset (T0) and at 7 days (T7). Cerebral blood...

After an acute ischaemic stroke (AIS), several inflammatory biomarkers have been investigated, but their predictive role on functional recovery remains to be validated. Here, we investigated the prognostic relevance of biomarkers related to atherosclerotic plaque calcification, such as osteopontin (OPN), osteoprotegerin (OPG) and the receptor...

BACKGROUND:Autoantibodies to ApolipoproteinA-1 (anti-ApoA-1 IgG) were shown to predict major adverse cardiovascular events and promote atherogenesis. However, their potential relationship with clinical disability and ischemic lesion volume after acute ischemic stroke (AIS) remains unexplored. MATERIALS AND METHODS: We included n=76 patients...