CHÁVEZ DE DIEGO , Sebastián

Genome expression involves the synthesis of messenger RNA (mRNA), a short lived molecule whose translation directs the synthesis of cellular proteins and that is subject to degradation after the translation process. Up to the date, mRNA synthesis and degradation has been considered as a linear phenomenon in which the above steps occur...

La finalidad del trabajo que aquí se presenta es contribuir al conocimiento de la función desarrollada por la actividad glutamato deshidrogenasa en las cianobacterias y de su relación con la asimilación de nitrógeno inorgánico, así como profundizar en las características moleculares de estas enzimas. Para ello se ha empleado una amplia...

In unstimulated mammalian cells and in Saccharomyces cerevisiae, the mouse mammary tumor virus (MMTV) promoter is silent and organized into positioned nucleosomes, one of which encompasses the binding sites for glucocorticoid receptor (GR) and nuclear factor I (NFI). Glucocorticoid induction in vivo involves a functional synergism between GR...

Gene expression is a highly regulated process that adapts RNAs and proteins content to the cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained by tight controls that act on both nuclear transcription and cytoplasmic mRNA stability. In recent years, it has been revealed that several RNA-binding proteins...

Método para el ensayo de la expresión del genoma de una muestra biológica y kit para su realización.El objeto de la presente invención consiste en un método y un conjunto de útiles para el ensayo de la distribución intragénica de las RNA polimerasas que s

Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the...

The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have high frequencies of DNA repeat recombination and chromosome loss. Here we report that HPR1 is required for transcriptional elongation. Transcription driven from constitutive and regulated yeast promoters cannot elongate...

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Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its posttranscriptional fate. In turn, mRNA degradation factors like Xrn1 are able to influence RNAPII-dependent transcription, making a feedback loop that contributes to mRNA homeostasis. In this work, we have...

Matrices de conductos capilares de utilidad química y biológica.El objeto de esta invención es un procedimiento para la fabricación de matrices de conductos capilares para la realización in situ de procesos de interacción química o biológica, formada por