DEBORA CAVIGLIA

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The aim of this work was the development of polymeric films from polysaccharides, containing olive mill wastewater (OMW) as antibacterial agent [1], for skin injures and wound healing. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, it should also maintain a wet medium at the wound interfacing and be easily removed...

Low-molecular-weight organic ammonium salts exert excellent antimicrobial effects by interacting lethally with bacterial membranes. Unfortunately, short-term functionality and high toxicity limit their clinical application. On the contrary, the equivalent macromolecular ammonium salts, derived from the polymerization of monomeric ammonium...

The aim of this research was the development of innovative eco-sustainable microwavemediated extractive procedures, using synthetic NADES (natural deep eutectic solvents), as eco-friendly solvents, to obtain new sustainable bioactive ingredients from beetroot stalks (an agri-food waste), according to the green extraction and circular economy...

Natural deep eutectic solvents (NaDES) represent a new generation of green, non-flammable solvents, useful as an efficient alternative to the well-known ionic liquids. They can be easily prepared and exhibit unexpected solubilizing power for lipophilic molecules, although those of a hydrophilic nature are mostly used. For their unique...

Difficult-to-treat bacterial infections involving resistant human and plant pathogens, severely afflict hospitals and concern the agri-food sector. Bacteria of the genus Pseudomonas can quickly become resistant to antibiotics and spread such resistance to other bacteria. Species such as P. aeruginosa, P. putida and P. fluorescens, which...

The global emerging infectious diseases caused by multi-drug resistant (MDR) bacteria necessitates worldwide systematic efforts to discover new effective antibacterial agents, replacing traditional antibiotics no longer active. For this purpose, we recently synthetized amino acid-modified cationic dendrimers and ammonium hydrochloride...

Multi-drug resistant bacterial strains (MDR) have become an increasing challenge to our health system, resulting in multiple classical antibiotics being clinically inactive today. As the denovo development of effective antibiotics is a very costly and time-consuming process, alternative strategies such as the screening of natural and synthetic...

Liposomal amphotericin B (Ambisome®) is the gold standard for the treatment and prevention of fungal infections both in the adult and pediatric populations. The lyophilized dosage form has to be reconstituted and diluted by hospital staff, but its management can be challenging due to the spontaneous tendency of amphotericin B to form aggregates...