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DELAGRANGE , Marine

Last name: DELAGRANGE

First name: Marine

July 24, 2023 (v1)

Journal article

Metadata-only

A genome-wide screen reveals new regulators of the 2-cell-like cell state

Gupta, Nikhil Yakhou, Lounis Albert, Julien Richard

In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse '2-cell-like cells' (2CLCs), which appear at low frequency in cultures of embryonic stem cells (ESCs). Because totipotency is not completely understood, we carried out a genome-wide CRISPR knockout screen in mouse ESCs,...

Uploaded on: September 5, 2023
July 24, 2023 (v1)

Journal article

Metadata-only

A genome-wide screen reveals new regulators of the 2-cell-like cell state

Gupta, Nikhil Yakhou, Lounis Albert, Julien Richard

In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse '2-cell-like cells' (2CLCs), which appear at low frequency in cultures of embryonic stem cells (ESCs). Because totipotency is not completely understood, we carried out a genome-wide CRISPR knockout screen in mouse ESCs,...

Uploaded on: October 11, 2023