DUCA , Maria

microRNAs (miRNAs) are emerging as novel biological targets for medicinal chemists to develop chemical tools for intracellular regulation. In this context, the discovery of small-molecule drugs targeting specific miRNAs and modulating their production or function represents a very promising approach that could be further developed for targeted...

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Abstract Targeting RNA with small molecules is a major challenge of current medicinal chemistry, and the identification and design of original scaffolds able to selectively interact with an RNA target remains difficult. Various approaches have been developed based on classical medicinal chemistry strategies (fragment‐based drug design, dynamic...

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La pandémie inédite liée à la COVID-19, maladie émergente causée par le SARS-CoV-2 (coronavirus 2 du syndrome respiratoire aigu sévère), touche tous les continents. La lutte contre cette infection passe par des mesures d'hygiène strictes, ainsi que le développement de vaccins et de nouvelles thérapies. La chémobiologie, domaine de recherche à...

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Natural tyrosinase inhibitors from herbal plants are promising therapeutic agents for skincare and cosmetic products. Natural curcuminoids exhibit weak antityrosinase properties. The structural modification of curcumin, the major curcuminoid from Curcuma longa, gave 14 analogues. The tyrosinase inhibitory activity of the natural curcuminoids...

Targeting biologically relevant noncoding RNAs using small molecules is currently one of the major challenges of medicinal chemistry but holds a great potential for future therapeutic applications. In this context, oncogenic microRNAs represent a particularly promising target, and various examples of RNA binders have been reported as inhibitors...

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The human immunodeficiency virus type-1 (HIV-1) Tat protein stimulates transcriptional elongation. Tat is involved in the transcription machinery by binding to the transactivation response region (TAR) RNA stem-loop structure, which is encoded by the 5' leader sequence found in all HIV-1 mRNAs. Herein, we report the rational design, synthesis,...

2-deoxystreptamine (2-DOS) conjugates with artificial nucleobases were designed and synthesized to inhibit pre-miR-372 processing into oncogenic miRNA and were discovered to be promising inhibitors when compared to their neomycin counterpart.

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