DUFIES , Océane

The innate immune detection of pathogenic microbes is crucial to enhance the immune response. During an infection, the activation of the innate immune system is the first step to establish an adaptative immune response. A physiological immune response is defined as adapted to the microbial environment and as an effectively resolved...

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NLRP3 is one of the best characterized innate immune cytosolic sensor. As part of the innate immune response, the NLRP3 inflammasome detects a wide range of danger signals such as pathogens, tissue damages, cellular stress. The priming and activation of NLRP3 lead to the formation of an oligomeric intracellular complex and to the recruitment...

Oxylipins are metabolized from dietary ω3 and ω6 polyunsaturated fatty acids and are involved in an inflammatory response. Adipose tissue inflammatory background is a key factor of metabolic disorders and it is accepted that dietary fatty acids, in terms of quality and quantity, modulate oxylipin synthesis in this tissue. Moreover, it has been...

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