DURAND , Matthieu

This paper investigates the use of constrained surrogate models to solve the multi-design optimization problem of a flexible hydrofoil. The surrogate-based optimization (EGO) substitutes the complex objective function of the problem by an easily evaluable model, constructed from a limited number of computations at carefully selected design...

In this work, we compare the use of Gaussian Process (GP) models for the constraints with a classification approach relying on a Least-Squares Support Vector Machine (LS-SVM). We propose several adaptations of the classification approach in order to improve the efficiency of the EGO procedure, in particular an extension of the binary LS-SVM...

International audience

Seven cases of translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) were referenced in the last World Health Organization's classification (2016), in a group of emerging/provisional RCC. The first three cases were pediatric, medullary-based, associated with sickle cell trait and showed a fusion of ALK with VCL. Thirteen cases...

Despite close follow-up of patients with native arteriovenous fistulas (AVFs), up to 10% experience thrombosis each year. The OSMOSIS Study (Osteopontin as a Marker of Stenosis) tested the hypothesis that the systemic osteopontin level, a pro-inflammatory mediator related to vascular remodelling and intimal hyperplasia, increases in AVF...

International audience

Objectives: To investigate the role of cancer-associated fibroblasts (CAFs) in clear cell renal cell carcinoma (ccRCC) with respect to tumour aggressiveness, metastasis development, and resistance to anti-angiogenic therapy (vascular endothelial growth factor receptor-tyrosine kinase inhibitors [VEGFR-TKI]).Patients and methods: Our study...

International audience

BACKGROUND: This national multicentre retrospective cohort study aimed to assess the long-term outcomes of dual kidney transplantation (DKT) and compare them with those obtained from single kidney transplantation (SKT). METHODS: Our first analysis concerned all first transplants performed between May 2002 and December 2014, from marginal...