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FALCHI F

Last name: FALCHI F

2011 (v1)

Publication

Metadata-only

Fyn kinase in brain diseases and cancer: the search for inhibitors.

SCHENONE, SILVIA BRULLO, CHIARA MUSUMECI, FRANCESCA

Fyn is a non-receptor tyrosine kinase belonging to the Src family kinases. It has been shown to play important roles in neuronal functions, including myelination and oligodendrocytes formation, and in inflammatory processes. It has also demonstrated its involvement in signaling pathways that lead to severe brain pathologies, such as Alzheimer's...

Uploaded on: March 27, 2023
2010 (v1)

Publication

Metadata-only

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors.

Radi M Crespan E Falchi F

This work is focused on the hit optimization of previously identified dual Src/Abl inhibitors based on 1,3,4-thiadiazole and thiazole scaffolds.

Uploaded on: May 11, 2023