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1993 (v1)PublicationUploaded on: March 31, 2023
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1987 (v1)Publication
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1997 (v1)Publication
The synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin- 4(1H)-ones 3, and of 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones 5 and their esters 6 is described. These derivatives were prepared in order to evaluate the influence on the pharmacological profile of alkyl...
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1996 (v1)Publication
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1998 (v1)Publication
The title esters I [R = Me, i-Pr, cyclopropyl, 3,4,5-(MeO)3C6H2; Ar = Ph, 4-ClC6H4, 4-MeOC6H4] were prepd. by regioselective acylation of (hydroxyethyl)triazones II with RCOCl. I were evaluated for antipyretic and anti-inflammatory activities. Nearly all derivs. and in particular I [R = i-Pr, 3,4,5-(MeO)3C6H2, Ar = 4-ClC6H4; R = cyclopropyl,...
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1994 (v1)Publication
The synthesis in excellent yields of 2,3-dihydro-6-mercapto-1,3,5-triphenyl-2-thioxo-4(3H)-pyrimidinone 3 and 5-ethoxycarbonyl-2,3-dihydro-6-mercapto-1,3-diphenyl-2-thioxo-4(3H)-pyrimidinone 4 by reaction of Me phenylacetate or di-Et malonate, resp., with Ph isothiocyanate (3 molar equivalents) and sodium hydride (2 molar equivalents) in DMF...
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1996 (v1)Publication
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Uploaded on: April 14, 2023 -
1998 (v1)Publication
A series of 1,3,4-thiadiazol-2(3H)-ones with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepd. and evaluated for antipyretic and antiinflammatory activities. All the title compds. exhibited antiinflammatory activity and were devoid of antipyretic properties.
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1997 (v1)Publication
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1987 (v1)Publication
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1994 (v1)Publication
The synthesis of 5-[[ω-(dialkylamino)alkoxy]methylene]-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-ones (I, n = 2, 3; NR2 = NEt2, 1-hexahydroazepinyl, etc.) by reaction of (+)-5-(hydroxymethylene)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-one with a series of ω-(chloroalkyl)dialkylamines in the presence of potassium carbonate is described. ...
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1992 (v1)Publication
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1995 (v1)Publication
The synthesis of novel 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles 4a-f, starting from N-phenyl-3,4-dihydro-1(2H)-oxonaphthalene-2-carbothioamide and the proper arylhydrazines, is described. Title compounds were evaluated for antiinflammatory, analgesic, antipyretic, antiarrhythmic, hypotensive, local anaesthetic and platelet...
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1990 (v1)Publication
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Uploaded on: March 31, 2023