GALATINI , Andrea

Enantiomerically pure 4,5-dihydro-1H-benzo[c]azepines with three contiguous stereogenic centers have been assembled by convergent strategy with a good control of diastereoselectivity. The two steps are as follows: an asymmetric organocatalytic Mannich reaction performed on Boc-imines of o-(azidomethyl)benzaldehydes, followed by a one-pot...

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Research progress is often promoted by unexpected results that open the way to new scenarios. In this communication, an unprecedented condensation of arylacetic acids and isocyanides and the unusual base-mediated rearrangement of the resulting products to give two novel classes of polysubstituted pyrrolones and pyrrolidinediones are reported.

Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and...

Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5'-pyrophosphate (Ap2A) has been synthesized from adenosine-5'-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate...

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The phytohormone abscisic acid (ABA), in addition to regulating physiological functions in plants, is alsoproduced and released by several mammalian cell types, including human granulocytes, where it stim-ulates innate immune functions via an increase of the intracellular cAMP concentration ([cAMP]i).We synthesized several ABA analogs and...

(1E,3Z)-1-Aryl-4-methanesulfonyl-2-nitro-1,3-butadienes, derived from the initial ring-opening of 3-nitrothiophene, have been found to undergo a facile base-induced cyclization leading to thiopyran S,S-dioxides, thus furnishing a further example of effective ring-enlargement from 5- to 6-membered sulfur heterocycles. These Compounds are...

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