GIACOMELLI , Emanuela

As Salvia exudates in a screening work have shown to possess inhibitory activity on the germination of Papaver rhoeas L. and Avena sativa L., a database for fast and efficient data collection among the various collaborating groups to be used in the following research steps to define the allelopathic potential of these species has been...

The surface exudate obtained by rinsing the aerial parts of Salvia adenophora with CH2Cl2 was subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS followed by semi-preparative RP-HPLC. Some known diterpenes have been isolated together with a new clerodane diterpenoid 1, identified by IR, NMR, including...

In this study, demethylfruticuline A (dfA) and fruticuline A (fA), two quinones representing the major diterpenoid components of the exudate produced by the aerial parts of Salvia corrugata, were assessed for their ability to modify surface characteristics, such as hydrophobicity, and to inhibit synthesis of biofilm in vitro by multiresistant...

In precedenti lavori1,2 è stato dimostrato come l'estratto di alcune specie di Salvia spp. è efficace come antigerminativo. In questi lavori sono stati applicati vari metodi di statistica classica che hanno confermato questa efficacia, ma non sono stati in grado di distinguere i livelli di efficacia ottenuti dalle diverse specie di Salvia....

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Demethylfruticulin A (SCO1) is the major diterpenoid component of the exudate produced by the trichomes of Salvia corrugata leaves. The activity of this new compound against Gram-positive pathogens [1] and the apoptosis effect on mammalian cell lines [2] were investigated in previous works. The aim of this study was to evaluate the possibility...

In this study we assessed whether demethyl fruticulin A (dfA) and fruticulin A (fA) two quinones that represent the mayor diterpenoid components of the exudate produced by the aerial parts of Salvia corrugata Vahl., were able to inhibit the synthesis of biofilm produced in vitro by multiresistant S. aureus and S. epidermidis. Five clinical...

In a screening work Salvia exudates have shown to possess inhibitory activity on the germination of Papaver rhoeas L. and Avena sativa L.. A database for fast and efficient data collection among the various collaborating groups has been developed in order to define the allelopathic potential of these species. Data about the effect of 13 species...

Frutticulina-A (FA) e Demetilfrutticulina-A (dFA), estratte da S.corrugata, sono state saggiate su batteri patogeni umani, anche multi-resistenti agli attuali farmaci antibiotici. Le due molecole sono risultate particolarmente attive nei confronti di batteri Gram-positivi come Staphylococcus aureus, S.epidermidis, Enterococcus faecium e E....

The outlook to use crop residues, cover crops and plant residues with high content of allelochemicals into the soil, as well as extracts of allelopathic plants, can provide selective weed control through the release of allelochemicals [1-3] and can contribute to the maintenance and the development of sustainable agro-ecosystems. As Salvia...

Abstract: In order to define the phytotoxic potential of Salvia species a database was developed for fast and efficient data collection in screening studies of the inhibitory activity of Salvia exudates on the germination of Papaver rhoeas L. and Avena sativa L.. The structure of the database is associated with the use of algorithms for...

A screening study on the anti-germination activity of the fresh aerial part plant exudates of thirteen species of Salvia L.(Lamiaceae) against Papaver rhoeas L. and Avena sativa L. in Petri dish and pot experiments, evaluated on the basis of statistical indices both classical ones [1, 2] and proposed by our group has been carried out. All...

Salvia L. is the largest genus of Lamiaceae (or Labiatae) family with more than 900 species of which ca. 26 are native to southern Africa like S. dolomitica Codd an aromatic perennial shrub found in the northeast province of Transvaal (1). This sage is also drought resistant (2) and extremely fragrant. S. dolomitica essential oil (EO) has been...

Our ongoing research to identify natural growth inhibitors with diterpene and triterpene skeletons exuding from the surface of the aerial parts of Salvia species led us to study Salvia miniata Fernald. Ten clerodane diterpenoids were found, along with three known diterpenes. Most of the isolated compounds from S. miniata inhibited the...

The lipophylic part of the surface exudate mixture obtained from Salvia adenophora Fernald, which previously showed herbicide activity against Papaver rhoeas L. and Avena sativa L. in dose-response studies and growth experiments [2], was considered for the isolation of cyclic metabolites of the polyunsaturated fatty acids. For these compounds...

Methicillin-resistant Staphylococcus aureus (MRSA) and S.epidermidis (MRSE) are Gram positive pathogens that represent a leading cause of serious human diseases worldwide and are responsible for substantial morbidity and mortality, both within the healthcare system and in the community [1,2]. We describe here the activity of three compounds, 12...

A study on thirteen Salvia species about the phytotoxicity of their aerial part exudates is reported. The selected species were: Salvia namaensis Schinz (1), Salvia fallax Fernald (2), Salvia disermas L. (3), Salvia chamaedryoides Cav. (4), Salvia confertiflora Pohl. (5), S. x jamensis J.Compton (6), Salvia buchananii Hedge (7), S. wagneriana...

The surface exudate of the aerial parts of S. adenophora [1], that showed germination total inhibition [2] against Papaver rhoeas L. and Avena sativa L. at 5mg/L in Petri dish experiments, subjected to column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS and MS2 experiments followed by semi-preparative RP-HPLC, yielded two new...

Gram-positive bacteria like Streptococcus agalactiae, Methicillin-resistant Staphylococcus aureus (MRSA), S.epidermidis (MRSE) and glycopeptyde resistant Enterococcus faecalis are becoming common causes of several types of severe infections, both in the community and in the hospital settings. Because of this scenario and the therapeutic...

In the course of our study on Salvia species with potential interest for phytotoxic activity we considered Salvia buchananii Hedge (Hedge, 1963) whose exudate showed activity against Papaver rhoeas L. and Avena sativa L. in a preliminary test (Bisio et al., 2010). The mixture, obtained by rinsing the plant material with CH2Cl2, was subjected to...

E' stato separato cromatograficamente l'essudato di Salvia miniata Fernald, specie messicana i cui estratti totali avevano dimostrato attività erbicida contro Papaver rhoeas L.e Avena sativa L. in test preliminari. Alcuni diterpeni isolati da questa specie hanno dimostrato attività fitotossica antigerminativa e attività inibente la crescita...

Nel corso di studi di screening per l'isolamento di sostanze con potenziale interesse allelopatico da piante aromatiche coltivate in Liguria nell'ambito del progetto "EU INTERREG Programme ALCOTRA France-Italie 2007-2013, Project de coopération simple "AROMA" n.068", è stata considerata Salvia adenophora Fernald (Subgenus: Calosphace, Sectio:...

Salvia miniata Fernald [1] is a Mexican species whose aerial part exudate showed herbicide activity against Papaver rhoeas L. and Avena sativa L. in a preliminary test [2]. Some diterpenes isolated from Salvia miniata had phytotoxic activity against the germination and the subsequent growth of Papaver rhoeas L. and Avena sativa L., thus...

Salvia adenophora Fernald [1] is a Mexican species whose aerial part exudate showed herbicide activity against Papaver rhoeas L. and Avena sativa L. in a preliminary test [2]. The surface exudate, obtained by rinsing the plant material with CH2Cl2, was subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS...

NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by a-hydroxy-b-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7a-methoxy-19- acetoxy-royleanone (4),...