GAY , Alexandre

p27 mediates cell cycle arrest by binding to and inhibiting cyclin-dependent kinase/cyclin complexes, but p27 can also contribute to pro-oncogenic signaling upon mislocalization to the cytoplasm. Cytoplasmic p27 stimulates cell migration by associating with RhoA and interfering with the exchange of GDP from RhoA stimulated by guanine nucleotide...

Digital servitization has emerged over the last years, at the convergence between digital- and service-oriented business strategies, leading manufacturing companies to transform their business models through the adoption of so-called Smart PSS (Smart Product-Service-Systems). As a contribution to the relatively recent scientific literature on...

Manufacturers have started exploiting the benefits of Internet-of-things and Artificial intelligence to offer solutions known as "Smart PSS." Recently, smart PSS engineering frameworks have begun appearing. Those frameworks lack guidelines on how to conduct risk management activities throughout the design and development of a smart PSS...

This paper explains the first steps of a smart PSS engineering approach, aimed at eliciting stakeholder needs, prototyping the value proposition, representing how the Original Equipment Manufacturer (OEM) will capture value and share it with a collaborative network of stakeholders while identifying and prioritizing risks from the value...

Cytokinesis begins in anaphase with the formation of the central spindle. PRC1 is a microtubule associated protein that plays an essential role in central spindle formation by crosslinking antiparallel microtubules. We have identified PRC1 as a novel binding partner for p27Kip1 (p27). p27 is a cyclin-CDK inhibitor that causes cell cycle arrest...