GUIDA P

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The N-methyl-D-aspartate receptor (NR) is a ligand-gated channel with unique properties, such as requirements for two different agonists, glutamate and glycine, Mg-mediated voltage-dependence and high calcium permeability, as well as several recognition sites for endogenous and exogenous modulators. NRs form tetrameric channels containing two...

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Ion channels are under-exploited membrane protein target class, due to the labour-intensive and low-throughput nature of traditional patch-clamp. Basic and clinical research require much efficiency, higher throughput and procedures simplification. Automatic devices, like the planar array patch-clamp (PAPC) may address these problems. Our...

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The purpose is to realize a Lab-On-Chip based device for cell screening and electrophysiological assay to introduce the Patch-Clamp as a routine clinical test. Patch-Clamping is the gold standard technique to investigate function and regulation of ion channels, specialized transmembrane proteins that play important roles in various...

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Ion channels (i.c.) are transmembrane proteins involved in nearly all physiological processes and in many human diseases. Nowadays, conventional Patch-Clamp (PC) is the gold technique for both ion channel drug discovery and research. However, i.c. remain an under-exploited target class, because of the PC laborious approach. Trends in i.c....