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HAARR , Marianne B.

Last name: HAARR

First name: Marianne B.

December 15, 2020 (v1)

Publication

Metadata-only

1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

Haarr, Marianne B. López López, Óscar Pejov, Ljupcho

The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (Ki values ranging from 0.23 to 1.4 μM).

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