ILTCHEVA , M

Lapatinib, a dual tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2), is prescribed for the treatment of patients with metastatic breast cancer overexpressing HER-2. Involvement of this drug in pulmonary carcinogenesis has been poorly investigated. We used murine...

The anti-diabetic drug metformin is endowed with anti-cancer properties. Epidemiological and experimental studies, however, did not provide univocal results regarding its role in pulmonary carcinogenesis. We used Swiss H mice of both genders in order to detect early molecular alterations and tumors induced by mainstream cigarette smoke. Based...

La metformina è un biguanide ipoglicemizzante ampiamente utilizzato per il trattamento del diabete di tipo 2. Negli ultimi anni, un'attenzione crescente nei confronti di questo farmaco è legata alla possibilità che la metformina possa anche agire come un farmaco antitumorale e possa quindi essere proposta come potenziale agente...