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JULLIAN , Valérie

Last name: JULLIAN

First name: Valérie

December 30, 2012 (v1)

Journal article

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Simalikalactone E (SkE), a new weapon in the armamentarium of drugs targeting cancers that exhibit constitutive activation of the ERK pathway

Robert, Guillaume Jullian, Valérie Jacquel, Arnaud

Simalikalactone E (SkE) is a quassinoid extracted from a widely used Amazonian antimalarial remedy. Although SkE has previously been shown to have cytostatic and/or cytotoxic activities in some tumor cell lines, its mechanism of action has not yet been characterized. We show here that SkE in the high nanomolar range inhibited the growth of...

Uploaded on: December 3, 2022
July 1, 2006 (v1)

Journal article

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Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

Laurent, Dominique Jullian, Valérie Parenty, Arnaud

As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary screening, the ethanolic crude extract of a new species of Xestospongia collected in Vanuatu was selected for its promising activity. A...

Uploaded on: February 28, 2023