LEDDA , Sabina

Hepatoma cells show alterations in the response to oxidative stress (decreased lipid peroxidation) and in xenobiotic metabolism enzymes (decreased P450, increased GST and ALDH3). This study examined the effect of lipid peroxidation on the expression of the above enzymes in two rat hepatoma cell lines (MH1C1 and 7777). To induce oxidative...

advanced glycation end-products (AGE) are linked to aging and correlated diseases. In this study we analysed both the cytotoxic and the oxidative/glycoxidative effects of 48 h exposure to subtoxic and subsequent toxic doses of AGE (ribose-glycated serum) in J774A.1 murine macrophage cells. the analysed end points (cytoxicity index, TBARs...

The interaction of reducing sugars, such as aldose, with proteins and the subsequent molecular rearrangements, produces irreversible advanced glycation end-products (AGEs), a heterogeneous class of non-enzymatic glycated proteins or lipids. AGEs form cross-links, trap macromolecules and release reactive oxygen intermediates. AGEs are linked to...