La síntesis de hidratos de carbono y derivados que posean propiedades de interés biológico (farmacológico) y tecnológico es uno de los objetivos generales de la investigación que se lleva a cabo en este Departamento. Un grupo importante de compuestos de este tipo es el constituido por los C-nucleósidos, que se caracterizan por tener un resto...
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September 24, 2018 (v1)PublicationUploaded on: December 4, 2022
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January 9, 2018 (v1)Publication
The direct borylation of hydrocarbons via C-H activation has reached an impressive level of sophistication and efficiency, emerging as a fundamental tool in synthesis because of the versatility offered by organoboron compounds. As a remarkable particularity, the catalytic systems originally developed for these reactions are relatively...
Uploaded on: March 27, 2023 -
June 3, 2022 (v1)Publication
An efficient, scalable and operationally simple one-pot, 2-step strategy for the nucleophilic formylation of trifluoromethyl ketones is presented. The key step is an unprecedented diaza-carbonyl-ene reaction of formaldehyde tert-butyl hydrazone and trifluoromethyl ketones under solvent-free conditions. This reaction proved to be very fast,...
Uploaded on: March 25, 2023 -
February 12, 2021 (v1)Publication
Abstract: Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity for the studied reactions. However, there are just a few examples of their use in hydrogen bonding organocatalysis. In this paper, we show the...
Uploaded on: December 5, 2022 -
February 19, 2018 (v1)Publication
The 1,3-dipolar cycloaddition of a variety of aromatic and aliphatic nitrile oxides to 2,5-trans-2,5-diphenylpyrrolidine derived acrylamide and cinnamamide efficiently affords the corresponding 4,5-dihydroisoxazole-5- carboxamides in a highly regio- and stereoselective manner. The cycloaddition of aliphatic nitrile oxides to the analogue...
Uploaded on: December 4, 2022