Little is known about the role of p38MAPK in human adipocyte differentiation. Here we showed that p38MAPK activity increases during human preadipocytes differentiation. Pharmacological inhibition of p38MAPK during adipocyte differentiation of primary human preadipocytes markedly reduced triglycerides accumulation and adipocyte markers...
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December 11, 2007 (v1)Journal articleUploaded on: December 4, 2022
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2014 (v1)Journal article
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2014 (v1)Journal article
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June 5, 2008 (v1)Journal article
Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through inhibition of liver glucose production and an increase in muscle glucose uptake. Recent studies suggest that metformin may reduce the risk of cancer, but its mode of action in cancer remains not elucidated. We investigated the effect of metformin on human...
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September 29, 2017 (v1)Journal article
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March 4, 2019 (v1)Journal article
Ubiquitin domain-containing protein 1 (UBTD1) is highly evolutionary conserved and has been described to interact with E2 enzymes of the ubiquitin-proteasome system. However, its biological role and the functional significance of this interaction remain largely unknown. Here, we demonstrate that depletion of UBTD1 drastically affects the...
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July 1, 2019 (v1)Journal article
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May 7, 2019 (v1)Journal article
Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1a) plays a pleiotropic role in the control of cancer cell metabolism and...
Uploaded on: February 22, 2023 -
May 7, 2019 (v1)Journal article
Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1a) plays a pleiotropic role in the control of cancer cell metabolism and...
Uploaded on: December 4, 2022 -
July 1, 2019 (v1)Journal article
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Uploaded on: December 4, 2022 -
July 1, 2019 (v1)Journal article
International audience
Uploaded on: February 22, 2023 -
December 2017 (v1)Journal article
Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake of calcium into the mitochondria, thus leading to...
Uploaded on: December 4, 2022