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Background: The non-receptor tyrosine kinases c-Abl and c-Src are overexpressed in various solid human tumors. Inhibition of their hyperactivity represents a mol. rationale in the combat of cancerous diseases. Here we examd. the effects of a new family of pyrazolo [3,4-d] pyrimidines on a panel of 11 different murine lung tumor progenitor...

In the last few years, several pyrrolo-pyrimidine derivatives have been either approved by the US FDA and in other countries for the treatment of different diseases or are currently in phase I/II clinical trials. Herein we present the synthesis and the characterization of a novel series of pyrrolo[2,3-d]pyrimidines, compounds 8a-j, and their...

This work is focused on the hit optimization of previously identified dual Src/Abl inhibitors based on 1,3,4-thiadiazole and thiazole scaffolds.