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August 22, 2019 (v1)Journal articleUploaded on: December 4, 2022
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October 2019 (v1)Journal article
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Uploaded on: December 4, 2022 -
May 2, 2002 (v1)Journal article
Human stromelysin 3 (ST3) is a matrix metalloproteinase (MMP) that has been implicated in cancer progression and in various tissue remodeling processes. Unlike most MMPs, ST3 is characterized by a distinct substrate specificity and a specific regulation and is not directly involved in extracellular matrix degradation. In the present study, we...
Uploaded on: July 9, 2023 -
2017 (v1)Book section
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December 15, 2010 (v1)Journal article
SUMMARY: Current challenges in microRNA (miRNA) research are to improve the identification of in vivo mRNA targets and clarify the complex interplay existing between a specific miRNA and multiple biological networks. MiRonTop is an online java web tool that integrates DNA microarrays or high-throughput sequencing data to identify the potential...
Uploaded on: December 4, 2022 -
May 15, 2018 (v1)Journal article
The obligate intracellular pathogenic bacterium, Ehrlichia rurninantiurn, is the causal agent of heartwater, a fatal disease in ruminants transmitted by Amblyomrna ticks. So far, three strains have been attenuated by successive passages in mammalian cells. The attenuated strains have improved capacity for growth in vitro, whereas they induced...
Uploaded on: December 4, 2022 -
2009 (v1)Journal article
MicroRNAs (miRNAs) are small non-protein-coding RNA that negatively control mRNA expression at a post-transcriptional level. They regulate various cellular functions and bioinformatic data suggest that they collectively control about 30% of human mRNAs. MiRNAs have been recently implicated in several carcinogenic processes, where they can act...
Uploaded on: December 3, 2022 -
May 1, 2022 (v1)Journal article
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Uploaded on: December 4, 2022 -
May 2022 (v1)Journal article
Abstract Thousands of unique noncoding RNAs (ncRNAs) are expressed in human cells, some are tissue or cell type specific whereas others are considered as house‐keeping molecules. Studies over the last decade have modified our perception of ncRNAs from transcriptional noise to functional regulatory transcripts that influence a variety of...
Uploaded on: March 3, 2024 -
August 27, 2023 (v1)Journal article
Abstract The epidermis is mostly composed of keratinocytes and forms a protecting barrier against external aggressions and dehydration. Epidermal homeostasis is maintained by a fine-tuned balance between keratinocyte proliferation and differentiation. In the regulation of this process, the keratinocyte-specific miR-203 microRNA is of the...
Uploaded on: November 27, 2023 -
2005 (v1)Journal article
Amphiregulin (AR) and insulin-like growth factor-1 (IGF1) are growth factors known to promote non-small cell lung cancer (NSCLC) survival. We have previously published that 1) AR and IGF1, secreted by H358 NSCLC cells, cooperate to protect those cells and H322 NSCLC cells from serum-starved apoptosis; 2) H358 cells resist Bax-induced apoptosis...
Uploaded on: December 4, 2022 -
May 20, 2005 (v1)Journal article
Amphiregulin (AR) and insulin-like growth factor-1 (IGF1) are growth factors known to promote non-small cell lung cancer (NSCLC) survival. We have previously published that 1) AR and IGF1, secreted by H358 NSCLC cells, cooperate to protect those cells and H322 NSCLC cells from serum-starved apoptosis; 2) H358 cells resist Bax-induced apoptosis...
Uploaded on: December 4, 2022 -
July 2011 (v1)Journal article
Osteosarcoma is the most common primary tumor of bone. The rapid development of metastatic lesions and resistance to chemotherapy remain major mechanisms responsible for the failure of treatments and the poor survival rate for patients. We showed previously that the HMGCoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor statin...
Uploaded on: December 3, 2022 -
2005 (v1)Journal article
Amphiregulin (AR) and insulin-like growth factor-1 (IGF1) are growth factors known to promote non-small cell lung cancer (NSCLC) survival. We have previously published that 1) AR and IGF1, secreted by H358 NSCLC cells, cooperate to protect those cells and H322 NSCLC cells from serum-starved apoptosis; 2) H358 cells resist Bax-induced apoptosis...
Uploaded on: October 11, 2023 -
July 18, 2011 (v1)Journal article
ABSTRACT: BACKGROUND: In severe obesity, as well as in normal development, the growth of adipose tissue is the result of an increase in adipocyte size and numbers, which is underlain by the stimulation of adipogenic differentiation of precursor cells. A better knowledge of the pathways that regulate adipogenesis is therefore essential for an...
Uploaded on: December 3, 2022 -
March 2013 (v1)Journal article
The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability. FXR1P plays an important role in normal muscle development, and its absence causes muscular abnormalities in mice, frog, and zebrafish. Seven...
Uploaded on: December 2, 2022 -
April 21, 2000 (v1)Journal article
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Uploaded on: December 4, 2022 -
March 2013 (v1)Journal article
The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability. FXR1P plays an important role in normal muscle development, and its absence causes muscular abnormalities in mice, frog, and zebrafish. Seven...
Uploaded on: October 11, 2023 -
August 8, 2011 (v1)Journal article
During chronic liver disease, tissue remodeling leads to dramatic changes and accumulation of matrix components. Matrix metalloproteases and their inhibitors have been involved in the regulation of matrix degradation. However, the role of other proteases remains incompletely defined. We undertook a gene expression screen of human liver fibrosis...
Uploaded on: December 4, 2022 -
April 2018 (v1)Journal article
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Uploaded on: December 4, 2022 -
July 2019 (v1)Journal article
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Uploaded on: December 4, 2022 -
July 28, 2017 (v1)Journal article
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Uploaded on: December 4, 2022