The FACT complex is an essential component of eukaryotic ce ... lls able to modify the chromatin structure allowing transcription by the RNA polymerase II. The FACT that this complex is essential in all organisms tested added to that it has been recently shown to be a target of curaxins, a potential novel anticancer compound, makes this complex...
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November 27, 2014 (v1)PublicationUploaded on: March 27, 2023
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January 12, 2023 (v1)Publication
The prevalence of non alcoholic fatty liver disease (NAFLD) has increased to 25% in the general population and could double by 2030. Liver fibrosis is the main indicator of morbidity and mortality and recent estimations suggest a substantial number of individuals with undiagnosed advanced liver disease. Strategies to monitor advanced fibrosis...
Uploaded on: March 24, 2023 -
March 3, 2015 (v1)Publication
No description
Uploaded on: March 27, 2023 -
November 15, 2023 (v1)Publication
Tissue-to-tissue crosstalk regulates organ function, according to growing data. This phenomenon is relevant for pancreatic b-cells and the liver, as both tissues are involved in glucose homeostasis and lipid metabolism. The ability to fine-tune regulation and adaptive responses is enabled through communication between pancreatic b-cells and the...
Uploaded on: November 25, 2023 -
November 24, 2022 (v1)Publication
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD...
Uploaded on: March 24, 2023 -
October 19, 2022 (v1)Publication
Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical trials. Methods After a systematic review of NAFLD...
Uploaded on: March 24, 2023 -
September 21, 2023 (v1)Publication
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced fibrosis and cirrhosis. In this study, we aimed to evaluate the prognosis of cirrhotic patients harboring this variant. We...
Uploaded on: October 11, 2023 -
October 11, 2022 (v1)PublicationLiver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a...
Uploaded on: March 24, 2023 -
May 23, 2023 (v1)Publication
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD...
Uploaded on: May 26, 2023 -
April 1, 2020 (v1)Publication
Background: A complex interplay between chromatin and topological machineries is critical for genome architec‑ ture and function. However, little is known about these reciprocal interactions, even for cohesin, despite its multiple roles in DNA metabolism. Results: We have used genome‑wide analyses to address how cohesins and chromatin structure...
Uploaded on: December 4, 2022 -
July 6, 2021 (v1)Publication
The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations....
Uploaded on: March 24, 2023 -
May 25, 2018 (v1)Publication
Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations of histones are sufficient to induce WGDs. Our results link these WGDs to a reduced incorporation of the histone variant...
Uploaded on: March 27, 2023 -
October 22, 2024 (v1)Publication
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Uploaded on: October 23, 2024