El presente trabajo de investigación pretende establecer un mejor conocimiento de la organización neuronal del GRV en la rata. Esta información es hoy necesaria para los estudios neurofarmacológicos y electrofisológicos (tanto en preparaciones in vivo como in vitro) que se realicen en la rata, como modelo experimental alternativo al gato. Por...
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November 27, 2014 (v1)PublicationUploaded on: March 27, 2023
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June 5, 2017 (v1)Publication
NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior. Likewise, the...
Uploaded on: March 27, 2023 -
April 28, 2017 (v1)Publication
In centrally related hearing loss, there is no apparent damage in the auditory system, but the patient is unable to hear sounds. In patients with cortical hearing loss (and in the absence of communication deficit, either total or partial, as in agnosia or aphasia), some attention-related or language-based disorders may lead to a wrong diagnosis...
Uploaded on: March 27, 2023 -
July 14, 2016 (v1)Publication
Se ha realizado un estudio de las calificaciones obtenidas por los alumnos de la asignatura de Fisiología Animal, en base a diferentes tests de evaluación. Las calificaciones obtenidas por los alumnos fueron extremadamente diferentes (p
Uploaded on: March 27, 2023 -
April 9, 2019 (v1)Publication
Acute or chronic injury to the central nervous system (CNS), causes neuronal death and irreversible cognitive deficits or sensory-motor alteration. Despite the capacity of the adult CNS to generate new neurons from neural stem cells (NSC), neuronal replacement following an injury is a restricted process, which does not naturally result in...
Uploaded on: March 27, 2023 -
February 27, 2015 (v1)Publication
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Uploaded on: March 27, 2023 -
February 7, 2024 (v1)Publication
It has been claimed that oxidative stress and the production of reactive oxygen radicals can contribute to neuron degeneration and might be one factor in the development of different neurological diseases. In our study, we have attempted to clarify how oxidative damage induces dose dependent changes in functional membrane properties of neurons...
Uploaded on: February 11, 2024 -
January 12, 2016 (v1)PublicationIlundáin Larrañeta, María Anunciación Ana Núñez Abades, Pedro Antonio Calonge Castrillo, María Luisa
Este trabajo describe la actividad docente desarrollada por los profesores de la asignatura de Fisiología Celular de la Facultad de Farmacia, durante el Curso Académico 1997-98, coincidiendo con la implantación del Nuevo Plan de Estudios de la Licenciatura de Farmacia. El desarrollo de la aplicación de la actividad tuvo como objetivo aplicar...
Uploaded on: December 4, 2022 -
September 20, 2022 (v1)Publication
Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear to be similar, suggesting...
Uploaded on: December 5, 2022 -
December 4, 2023 (v1)Publication
La presente invención escribe un método electrofisiológico y un kit consistente en una concentración de 10 µM de hidroperóxido de cumeno puro en líquido cefalorraquídeo para cuantificar los efectos de la toxicidad sobre las propiedades intrínsecas de las neuronas de la corteza motora a los 5 minutos de exposición a la acción tóxica y su uso en...
Uploaded on: December 6, 2023 -
March 2, 2022 (v1)Publication
Vitamin D is an essential fat-soluble vitamin that participates in several homeostatic functions in mammalian organisms. Lower levels of vitamin D are produced in the older population, vitamin D deficiency being an accelerating factor for the progression of the aging process. In this review, we focus on the effect that vitamin D exerts in the...
Uploaded on: December 4, 2022 -
March 24, 2022 (v1)Publication
A small library of phorbol 12,13-diesters bearing low lipophilicity ester chains was prepared as potential neurogenic agents in the adult brain. They were also used in a targeted UHPLC–HRMS screening of the latex of Euphorbia resinifera. Two new 12-deoxy-16-hydroxyphorbol 13,16-diesters were isolated, and their structures were deduced using...
Uploaded on: March 25, 2023 -
February 15, 2021 (v1)Publication
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to conventional therapies, including temozolomide, the most widely used chemotherapeutic agent in the treatment of GBM. Within the tumor, the presence of glioma stem cells (GSC) seems to be the reason for drug resistance. The discovery of GSC has boosted...
Uploaded on: March 26, 2023 -
April 6, 2018 (v1)Publication
Coincidiendo con la implantación del Nuevo Plan de Estudios de la Licenciatura de Farmacia durante el Curso Académico 1997-98, los profesores de la asignatura de Fisiología Celular de la Facultad de Farmacia decidimos utilizar programas de ordenador interactivos, basados en la tecnología multimedia, para la enseñanza práctica de la mencionada...
Uploaded on: December 4, 2022 -
January 26, 2022 (v1)Publication
Achieving the distinctive complex behaviors of adult mammals requires the development of a great variety of specialized neural circuits. Although the development of these circuits begins during the embryonic stage, they remain immature at birth, requiring a postnatal maturation process to achieve these complex tasks. Understanding how the...
Uploaded on: December 4, 2022 -
April 19, 2022 (v1)Publication
Hippocampal neurogenesis has widely been linked to memory and learning performance. New neurons generated from neural stem cells (NSC) within the dentate gyrus of the hippocampus (DG) integrate in hippocampal circuitry participating in memory tasks. Several neurological and neuropsychiatric disorders show cognitive impairment together with a...
Uploaded on: March 25, 2023 -
May 23, 2022 (v1)Publication
Neuroinflammation underlies neurodegenerative diseases. Herein, we test whether acute colon inflammation activates microglia and astrocytes, induces neuroinflammation, disturbs neuron intrinsic electrical properties in the primary motor cortex, and alters motor behaviors. We used a rat model of acute colon inflammation induced by dextran...
Uploaded on: December 4, 2022