OPOTA , Onya

Bacillus sphaericus that produces the binary toxin (Bin) is used as a biopesticide for the control of Anopheles and Culex mosquitoes that bear infectious disease agents. It is crucial to fully elucidate Bin cellular mode of action in the aim to improve formulations based on B. sphaericus, and to dispense alternatives tools against the emergence...

The binary toxin (Bin) from Bacillus sphaericus exhibits a highly insecticidal activity against Culex and Anopheles mosquitoes. The cytotoxicity of Bin requires an interaction with a specific receptor present on the membrane of midgut epithelial cells in larvae. A direct correlation exists between binding affinity and toxicity. The toxin binds...

International audience

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for...