PEDEMONTE , Federico

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A wide range of environmental pollutants called Endocrine Disrupters (ED) can mimic steroid hormones causing adverse health effects. Previous studies have demonstrated that bisphenol-A (BPA) represents a relevant compound within chemicals present in water and sediments coming from a polluted area of the Po plain. This study is aimed to...

DMRT1 has been suggested to be the first conserved gene involved in sex differentiation found from invertebrates to human. DMRT1 genes have been characterised in several species of fish, but have not been isolated in carp (Cyprinus carpio). Carp has been widely studied as an indicator of pollution in watercourses throughout South-Europe, and so...

Exposure to Endocrine-Disrupting Chemicals (EDCs) is suspected to be the cause for the increasing number of reproductive disorders in wildlife. It is well established that many chemicals in the environment can interfere with signalling mechanisms/hormonal regulation of fish at concentrations considerably below those causing cellular toxicity....

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A number of man-made chemicals has been shown to mimic endogenous hormones and to induce alterations of reproductive physiology in wild populations. Of particular importance are compounds that mimic estrogens and androgens (and their antagonists), because of their central role in reproductive function. In this study, male and female adult South...

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Crypt neurons are olfactory receptor cells located in the olfactory epi- thelium of fishes. They exhibit a peculiar and well-recognizable morphol- ogy, although their odorant specificity is still unknown. Data on their appearance during development are few and far between. This study set out to identify the time at which crypt neurons appeared...

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The effects on gonad morphology, sex steroid and vitellogenin (VTG) plasma levels were investigated in k2 carps exposed to graded concentrations of tamoxifen, ethynyl-oestradiol (EE2), flutamide and methyl-dihydro-testosterone (MDHT), four chemicals chosen as prototype of anti-estrogenic, estrogenic, anti-androgenic and androgenic activities,...

The objective of this study was to correlate morphological and biochemical parameters of reproductive activity in fish exposed to graded concentrations of endocrine disrupting chemicals. Two-year-old carps were exposed for two weeks to graded concentrations of ethynyl-estradiol, tamoxifen, and flutamide. For each chemical, morphological...

Many diseases are the outcome of a complex inter-relationship between multiple genetic and environmental factors. Research suggests that individual susceptibility is influenced more by certain genes than by exposure to environmental agents. The startup of Human genome project has induced the activation, by NIEHS, of a companion project: the...

A wide range of environmental pollutants commonly termed endocrine disrupters (ED) can mimic steroid hormones causing adverse health effects. Recent studies showed that bisphenol A (BPA) together with other estrogenic chemicals, may be responsible for the disrupting effects observed in fish of the middle River Po. The present study has...

Po River, the principal Italian water course, and its affluent receive compounds that can act as endocrine disrupters (EDs) in fish community. The Lambro River is a tributary of the Po River and drains a heavily industrialised and densely inhabited sub-basin of the main river; the stretches located upstream and downstream of their confluence...

The Po river, the principal Italian watercourse, and its affluent collect compounds that can act as endocrine disrupters (EDs) in fish community. Lambro River, is the most polluted tributary that drains a heavily industrialised and densely inhabited sub-basin of the main river. Recently, Lambro contamination by PCDDs and PCDFs, at...