PELICCI , Simone

The eukaryotic cell nucleus is composed by heterogeneous biological structures, such as the nuclear envelope (NE) and chromatin. At a morphological level, chromatin organization and its interactions with nuclear structures, such as nuclear lamina (NL) and nuclear pore complex (NPC), are suggested to play an essential role in the regulation of...

The structural state of DNA in mammalian nucleus of living cells corresponds to varying levels of chromatin organization, ranging from the nucleosomes to higher order structures. This varying degree of hierarchical compaction is integral to genome functions, allowing or preventing access to several genetic nuclear factors (epigenetic,...