POULET , Sylvain

RNA represents an extremely original and promising therapeutic target for the discovery of innovative drugs in a large number of pathologies. Several drugs currently on the market target RNA such as some antibiotics (aminoglycosides, tetracyclines, macrolides) or Risdiplam approved in 2020 as a modulator of alternative splicing in patients with...

2-deoxystreptamine (2-DOS) conjugates with artificial nucleobases were designed and synthesized to inhibit pre-miR-372 processing into oncogenic miRNA and were discovered to be promising inhibitors when compared to their neomycin counterpart.