SÁNCHEZ FIDALGO , Susana

Los fármacos con acción anticolinérgica son ampliamente utilizados en la farmacoterapia de los pacientes mayores. Las características de estos pacientes, sus cambios farmacocinéticos/farmacodinámicos y su menor actividad anticolinérgica basal, hacen que tengan mayor riesgo de sufrir reacciones adversas anticolinérgicas, tanto centrales como...

Los medicamentos anticolinérgicos son utilizados en multitud de indicaciones, siendo un área de preocupación por sus reacciones adversas (RA). Las personas mayores, por su multimorbilidad y cambios farmacocinéticos, tienen mayor riesgo de padecerlas. Existen escalas anticolinérgicas que estiman el riesgo de desarrollar RA anticolinérgicas....

The objective of the present study has been to advance knowledge of the gastric role played by the amino acid L-Arginine (L-Arg) in the evolution of a chronic gastric ulcer. In order to clarify it, L-Arg alone or together with Ibuprofen have been administrated in an experimental acetic acid chronic ulcer, analysing characteristic parameters of...

Objective: The aim of the study was to evaluate the concordance among 10 anticholinergic scales for the measurement of anticholinergic drug ex posure in at-risk elderly complex chronic patients in primary care. Methods: An 8-month cross-sectional, multicenter study was carried out in a cohort of complex chronic patients older than 65 years in...

Extra virgin olive oil (EVOO) is obtained from the fruit of the olive tree Olea europaea L. Phenolic compounds present in EVOO have recognized anti-oxidant and anti-inflammatory properties. However, the activity of the total phenolic fraction extracted from EVOO and the action mechanisms involved are not well defined. The present study was...

Background and objective: There are barriers to deprescription that hinder its implementation in clinical practice. The objective of this study was to analyse the main barriers and limitations of the deprescription process perceived by physicians who care for multipathological patients. Materials and methods: The "deprescription questionnaire...

Background: Deprescription is the revision of the therapeutic plan with the aim of simplifying it, taking into account patient preferences, prognosis and environment. This strategy is particularly relevant in older patients, mostly polymedicated individuals, since they are exposed to numerous adverse effects and interactions and tend to have...

Objective LESS-CHRON (List of Evidence-Based Deprescribing for Chronic Patients) and STOPPFrail (Screening Tool of Older Persons' Prescriptions in Frail adults with limited life expectancy) are criterion-based deprescribing tools. This study aimed to identify the prevalence of potentially inappropriate medications (PIMs) with these tools in an...

Background Drug interactions (DIs) are a significant cause of medicationrelated problems. The aging population, high chronic diseases prevalence and polypharmacy are closely associated factors. Aim of the review To study the prevalence, types and associated factors of DIs in multimorbidity patients of over 65 years of age in primary care....

This study was aimed to know the immunomodulatory effects of defined extra virgin olive oil (EVOO) diets on indomethacin induced gastric lesion. Methods: Different groups were fed with diets: standard diet (5 g of fat/100 g of diet), and EVOO-5 and EVOO-20 (5 or 20 g/100 g of diet, respectively). After 6 weeks, each dietary group was divided...

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The immune system is somehow related to all the metabolic pathways, in a bidirectional way, and the nutritional interventions affecting these pathways might have a relevant impact on the inflammatory status of the individuals. Food-derived peptides have been demonstrated to exert several bioactivities by in vitro or animal studies. Their...

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Background Nowadays, it is difficult to establish a specific method of intervention by the pharmacist and its clinical repercussions. Our aim was to identify interventions by pharmacists integrated within an interdisciplinary team for chronic complex patients (CCPs) and determine which of them produce the best results. Methods A systematic...

Anticholinergic burden (AB) is related to cognitive impairment (CI) and older complex chronic patients (OCCP) are more susceptible. Our objective was to evaluate the predictive value of ten anticholinergic scales to predict a potential CI due to anticholinergic pharmacotherapy in OCCP. An eight-month longitudinal multicentre study was carried...

Antecedentes y objetivo: En 2017 se desarrolló un cuestionario en italiano que tenía como objetivo deter minar las percepciones de los clínicos ante la desprescripción en población de edad avanzada. El objetivo fue traducir y adaptar transculturalmente al espanol ˜ este cuestionario de desprescripción. Métodos: Traducción directa y...

Purpose The aim of this work was to investigate the association between anticholinergic burden or anticholinergic drug use and xerostomia and/or xerophtalmia in elderly through a systematic review of the published literature. Methods A search was carried out in 3 databases (CINAHL, Embase and Pubmed). Studies conducted in people ≥65 years of...

The association between anticholinergic burden and constipation is not well defined and documented; for this reason, a systematic review was carried out in five databases (Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus), including studies assessing the correlation between anticholinergic burden, and...