SANTANA GARRIDO , Álvaro

Figura 1_ MTT and DCFHDA levels.pzfx: data corresponding to manuscript Figure 1 on cell viability and ROS. Figura 2_CAT.pzfx: data corresponding to Figure 2 in manuscript indicating protein and gene expression of CAT-1. Figura 2_Datos_vi.pzfx: data corresponding to Figure 2 in manuscript indicating L-arginine initial velocity. Figura...

Arterial hypertension (AH) contributes to the excessive production of reactive oxygen species (ROS) that promote hypertensive-mediated organ damage (HMOD) via different mechanisms, including inflammatory and profibrotic processes. The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system has been postulated as the main source of...

El estrés oxidativo se asocia con diversas enfermedades oculares y sistémicas y con el proceso de envejecimiento. Muchos estudios relacionan la hipertensión arterial (HTA) con una variación del estado oxidativo, y cómo este hecho puede favorecer la aparición de diferentes patologías en diversos órganos. Además, estudios epidemiológicos...

Scope Our laboratory has previously described the antioxidant and anti-inflammatory potential of a wild olive (acebuche, ACE) oil against hypertension-associated vascular retinopathies. The current study aims to analyze the antifibrotic effect of ACE oil on the retina of hypertensive mice. Methods and results Mice are rendered hypertensive by...

Other than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, all these systemic, cellular, and molecular changes in maternal physiology also make the mother and the fetus more prone to...

Oxidative stress plays a key role in several systemic and ocular diseases, including hypertensive eye diseases. In this context, we previously showed that oral administration of wild olive (acebuche, ACE) oil from Olea europaea var. sylvestris can counteract ocular damage secondary to arterial hypertension by modulating excess reactive oxygen...

La presente invención pertenece al sector de la medicina y la nutrición, y busca paliar los problemas del daño retiniano asociado a la hipertensión arterial mediante la utilización del aceite de acebuchina, en la preparación de un medicamento, diferentes fórmulas farmacéuticas, sola o asociada a otros agentes antihipertensivos, o como un...

Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree's...

Arterial hypertension (AH) leads to oxidative and infammatory imbalance that contribute to fbrosis development in many target organs. Here, we aimed to highlight the harmful efects of severe AH in the cornea. Our experimental model was established by administration of NG-nitro-L-arginine-methyl-ester (L-NAME) to C57BL/6 mice, which were...

Background: Echinomycin (EKN), an inhibitor of hypoxia-inducible factor (HIF)-1 DNA-binding activity, has been implied as a possible therapeutic agent in ischemic diseases. Here, we assess EKN in hypoxia-driven responses in vitro using human primary adult retinal pigment epithelium cells (aRPE) and retinal endothelial cells (hREC), and in vivo...

Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti‐inflammatory potential of the wild olive tree (namely, acebuche (ACE) for the primitive Spanish lineages)....

Despite numerous reports on the beneficial effects of olive oil in the cardiovascular context, very little is known about the olive tree's wild counterpart (Olea europaea, L. var. sylvestris), commonly known as acebuche (ACE) in Spain. The aim of this study was to analyse the possible beneficial effects of an extra virgin ACE oil on vascular...

Sunitinib (Su) is a tyrosine kinase inhibitor with antiangiogenic and antineoplastic effects that is recommended therapy for renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. Arterial hypertension is one of the adverse effects observed in the treatment with Su. The aim of this work was to deepen our...

Preeclampsia (PE) is a pregnancy-specific disorder characterized by the new onset of hypertension plus proteinuria and/or end-organ dysfunction. Here, we investigate the role of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system as a major component of reactive oxygen species generation, in a rodent model of early-onset...

Glaucoma is characterized by cupping of the optic disc, apoptotic degeneration of retinal ganglion cells (RGCs) and their axons, and thinning of the retinal nerve fiber layer, with patchy loss of vision. Elevated intraocular pressure (IOP) is a major risk factor for hypertensive glaucoma and the only modifiable one. There is a need to find...