SANTIESTEBAN TOCA , Cosme E.

This work proposes an improvement of the multi-objective evolutionary method for the protein residue-residue contact prediction called MECoMaP. This method bases its prediction on physico chemical properties of amino acids, structural features and evolutionary information of the proteins. The evolutionary algorithm produces a set of decision...

In this paper, we focus on protein contact map prediction. We describe a method where contact maps are predicted using decision tree-based model. The algorithm includes the subsequence information between the couple of analyzed amino acids. In order to evaluate the method generalization capabilities, we carry out an experiment using 173...

In this paper, we focus on protein contact map prediction, one of the most important intermediate steps of the protein folding prob lem. The objective of this research is to know how short-range interac tions can contribute to a system based on decision trees to learn about the correlation among the covalent structures of a protein residues....

The problem of protein structure prediction (PSP) represents one of the most important challenges in computational biology. Determining the three dimensional structure of proteins is necessary to under stand their functions at molecular level. The most representative soft computing approaches for solving the protein tertiary structure...

Protein structure prediction consists in determining the thre e-dimensional conformation of a protein based only on its amino acid se quence. This is currently a difficult and significant challenge in structural bioinformatics because these structures are necessary for drug designing. This work proposes a method that reconstructs protein...

We present a multi-objective evolutionary approach to predict protein contact maps. The algorithm provides a set of rules, inferring whether there is contact between a pair of residues or not. Such rules are based on a set of specific amino acid properties. These properties determine the particular features of each amino acid represented in the...