Over the last 20 years the availability of magnetic resonance imaging and positron-emission tomography technologies as well as of cerebrospinal fluid biomarkers has allowed research and clinical approach to Alzheimer's disease (AD) to move towards the earliest manifestations of the disease. This new approach resulted in an increasing knowledge...
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2017 (v1)PublicationUploaded on: April 14, 2023
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2020 (v1)Publication
People with type 2 diabetes are at an increased risk of cognitive impairment and dementia (including Alzheimer's disease), as well as subtle forms of cognitive dysfunction. Current diabetes guidelines recommend screening for cognitive impairment in groups at high risk and providing guidance for diabetes management in patients with diabetes and...
Uploaded on: April 14, 2023 -
2019 (v1)Publication
The diagnosis of mild cognitive impairment (MCI) refers to cognitive impairment not meeting dementia criteria. A survey among members of the American Association of Neurology (AAN) showed that MCI was considered a useful diagnosis. Recently, research criteria have been proposed for the diagnosis of Alzheimer's disease (AD) in MCI based on AD...
Uploaded on: April 14, 2023 -
2014 (v1)Publication
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Uploaded on: March 27, 2023 -
2017 (v1)Publication
Lifestyle factors have been associated with the risk of dementia, but the association with Alzheimer's disease (AD) remains unclear.
Uploaded on: April 14, 2023 -
2015 (v1)Publication
Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association...
Uploaded on: April 14, 2023 -
2019 (v1)Publication
BACKGROUND: Biomarker-based risk predictions of dementia in people with mild cognitive impairment are highly relevant for care planning and to select patients for treatment when disease-modifying drugs become available. We aimed to establish robust prediction models of disease progression in people at risk of dementia. METHODS: In this...
Uploaded on: April 14, 2023