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November 27, 2014 (v1)PublicationUploaded on: December 5, 2022
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July 19, 2017 (v1)Publication
La transferencia conjugativa de R100, un plásmido de la familia de F, ocurre a frecuencias más altas en ausencia de metilación Dam. Los mutantes Dam– contienen menores cantidades de RNA FinP que la estirpe silvestre; ello sugiere que la metilación Dam regula la síntesis de RNA FinP. La carencia de proteína reguladora de respuesta a la leucina...
Uploaded on: December 4, 2022 -
August 20, 2021 (v1)Publication
The repositioning of drugs already approved by regulatory agencies for other indications is an emerging alternative for the development of new antimicrobial therapies. The repositioning process involves lower risks and costs than the de novo development of novel antimicrobial drugs. Currently, infections by adenovirus show a steady increment...
Uploaded on: March 25, 2023 -
November 24, 2022 (v1)Publication
Objectives: To evaluate whether simplification of antiretroviral treatment to dual therapy (DT) negatively impacts immune recovery (IR), immune activation and inflammation (IA/I), and HIV reservoir. Methods: An open-label, single-centre, randomized controlled trial conducted in adult virologically suppressed HIV-infected patients on triple...
Uploaded on: March 24, 2023 -
May 25, 2023 (v1)Publication
Background The SARS-CoV-2 pandemic has overwhelmed hospital services due to the rapid transmission of the virus and its severity in a high percentage of cases. Having tools to predict which patients can be safely early discharged would help to improve this situation. Methods Patients confirmed as SARS-CoV-2 infection from four Spanish...
Uploaded on: May 26, 2023 -
October 28, 2022 (v1)Publication
SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study,...
Uploaded on: December 5, 2022 -
April 27, 2016 (v1)Publication
Motivación: El adenovirus humano (HAdV) es un virus que causa infecciones autolimitadas y leves en individuos inmunocompetentes, en cambio, en pacientes inmunodeprimidos las infecciones suelen ser de caracter grave, presentando elevada morbilidad y mortalidad. En la actualidad no existe un antiviral específico para tratar...
Uploaded on: December 4, 2022