En esta comunicación se expone el proceso de aplicación de un nuevo modelo de enseñanza-aprendizaje cuyo objetivo es incentivar el conocimiento de estereoquímica (la química en tres dimensiones) por parte de alumnos de primer curso del grado en Farmacia. Para ello, se diseñó un modelo metodológico y un mapa de contenidos que permitió obtener...
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November 14, 2023 (v1)PublicationUploaded on: November 25, 2023
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November 27, 2014 (v1)Publication
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Uploaded on: December 4, 2022 -
April 27, 2016 (v1)Publication
Motivation: Only a few cells in the human organism keep their ability to regenerate. Hence, modern medical research intends to develop new ways to cultivate these cells with high regenerative capacity with the aim to reconstruct damaged organs and tissues. This is a challenging process currently carried out in 2D cultures, which do not reflect...
Uploaded on: December 5, 2022 -
December 22, 2021 (v1)Publication
Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble to form different types of macromolecular structures such as micelles, monolayer vesicles, bars, sheets and tubes. In...
Uploaded on: March 25, 2023 -
July 4, 2016 (v1)Publication
Phosphinite thioglycosides I for which a modular synthetic approach is reported, were found highly efficient catalyst precursors for palladium(0)-catalyzed asymmetric substitution. Both enantiomers of the allylated products have been obtained with high ee (up to 96%) using natural sugars as catalyst precursors.
Uploaded on: December 4, 2022 -
June 23, 2016 (v1)Publication
Reported is an efficient approach to the synthesis of water-soluble proline-coated gold nanoparticles through a place exchange reaction between pentanethiolate stabilized gold nanoparticles and a proline-tethered amphiphilic thiol. Preliminary studies show that the nanocatalyst is highly active in an enamine type aldolisation leading to the...
Uploaded on: March 27, 2023 -
September 3, 2024 (v1)Publication
El absentismo estudiantil, la dificultad para mantener la atención en clase y la falta de organización del trabajo diario fuera del aula son tres de los problemas más importantes a los que se enfrenta el profesorado universitario, sobre todo en asignaturas de los primeros cursos, consideradas por el alumnado como difíciles, como es el caso de...
Uploaded on: September 4, 2024 -
January 16, 2024 (v1)Publication
An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has been developed, using N-isopropylsulfinylimines as a starting chiral material, proving the superiority of the isopropyl group as a chiral inducer over the tert-butyl group in the case of hindered N-sulfinylimines.
Uploaded on: January 19, 2024 -
January 31, 2024 (v1)Publication
Monosulfinamides and C2-symmetric bis-sulfinamides are convenient neutral chiral promoters in the allylation of acyl hydrazones, the nature of the spacer and the substituent at the sulfinyl sulfur are key elements for the enantioselectivity of the process.
Uploaded on: February 4, 2024 -
June 22, 2016 (v1)Publication
To take full advantage of the remarkable applications of carbon nanotubes in different fields, there is a need to develop effective methods to improve their water dispersion and biocompatibility while maintain- ing their physical properties. In this sense, current approaches suffer from serious drawbacks such as loss of electronic structure...
Uploaded on: December 4, 2022 -
May 17, 2017 (v1)Publication
The application of phosphinite-thioglycosides and phosphine-thioglycosides ligands in the Rh(I)-catalyzed 1,4-addition of phenylboronic acid to cyclohexenone is reported. Among the ligands tested, phosphinite-thioglycoside 3 and phosphine-thioglycoside 10, bearing a 1,2-cis arrangement of the two heteroatoms, have exhibited the best results in...
Uploaded on: December 4, 2022 -
January 8, 2024 (v1)Publication
Different studies using Aprepitant, a NK1R antagonist currently used as a clinical drug for treating chemotherapy-related nausea and vomiting, have demonstrated that pharmacological inhibition of NK1R effectively reduces the growth of several tumor types such as neuroblastoma (NB). In a previous work, we demonstrated that a series of...
Uploaded on: January 10, 2024 -
November 26, 2021 (v1)Publication
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present study, we report on the synthesis of carbohydrate-based NK1R antagonists and their evaluation as anticancer agents against a wide range of cancer cells. All of the prepared compounds,...
Uploaded on: March 25, 2023 -
September 13, 2023 (v1)Publication
A series of enantiopure chiral NH2/SO palladium complexes have been synthesised with high yields by treating the corresponding tert-butylsulfinamide/sulfoxide derivatives with Pd(CH3CN)2Cl2. The enantiopure chiral ligands were prepared by stereoselective addition of tert-butyl or phenyl methylsulfinyl carbanions to different...
Uploaded on: October 18, 2023