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ZANOLI S

Last name: ZANOLI S

2010 (v1)

Publication

Metadata-only

Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms

Crespan E Radi M Zanoli S

The tyrosine kinase Src and its close homolog Abl, both play important roles in chronic myelogenous leukemia (CML) progression and Imatinib resistance. No clin. approved inhibitors of the drug-resistant AblT315I exist to date. Here, we present a thorough kinetic anal. of two potent dual Src-Abl inhibitors towards wild type Src and Abl, and...

Uploaded on: April 14, 2023
2010 (v1)

Publication

Metadata-only

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors.

Radi M Crespan E Falchi F

This work is focused on the hit optimization of previously identified dual Src/Abl inhibitors based on 1,3,4-thiadiazole and thiazole scaffolds.

Uploaded on: May 11, 2023