ALMAIRAC , Fabien

There is great interest but little understanding in how cancer stem cells arise. Here we show that tumor cells exhibiting stem-like properties and expression of stemness(CD133) and pluripotency markers (SOX2, NANOG, OCT4), can arise from differentiated tumor cells that are isolated from human glioblastomas. These cells could transit from a more...

Introduction : La voie dorsale du langage, sous-tendue par le faisceau arqué, est impliquée dans les processus phonologiques. La voie ventrale est impliquée dans les traitements sémantiques du langage, mais la connectivité qui la sous-tend est discutée. Objectifs : Démontrer l'implication du faisceau fronto-occipital inférieur (FOFI) dans la...

International audience

To ensure appropriate blood supply through the brain, the cerebral blood vessels, neurons, and as-trocyte glial cells must interact according to complex mechanisms. This interaction, named "neurovascular coupling" (NVC), describes the link between neuronal activity and cerebral blood flow (CBF) changes. 25 Several methods have been developed to...

International audience

We aimed to link macro-and microstructure measures of brain white matter obtained from diffusion MRI with effective connectivity measures based on a propagation of cortico-cortical evoked potentials induced with intrasurgical direct electrical stimulation. For this, we compared streamline lengths and log-transformed ratios of streamlines...

Propagation of Cortico-Cortical Evoked Potentials (CCEPs) varies depending on numerous structural features of brain tissue. In this work, we show that dMRI-based connectivity enriched with microstructure data has the potential to measure cortico-cortical communication as it predicts CCEP-based effective connectivity. Our multiple linear...

Peritumoral edema prevents fiber tracking from diffusion tensor imaging (DTI). A free-water correction may overcome this drawback, as illustrated in the case of a patient undergoing awake surgery for brain metastasis. The anatomical plausibility and accuracy of tractography with and without free-water correction were assessed with functional...

We aimed to validate structural connectivity measures based on diffusion MRI with Electrical Stimulation (ES) of the human brain cortex. For this, we combined white matter fiber tractography with propagation of Cortico-Cortical Evoked Potentials (CCEPs) induced by in-trasurgical ES in the language system of brain tumor patients. Our results...

International audience

Background The differential diagnosis between infiltrative glioma (IG) and benign or curable glial lesions, such as gliosis, pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor, ganglioglioma, or demyelinating disease, may be challenging for the pathologist because specific markers are lacking. Recently, we described a strong EGFR...

Background The differential diagnosis between infiltrative glioma (IG) and benign or curable glial lesions, such as gliosis, pilocytic astrocytoma, dysembryoplastic neuroepithelial tumor, ganglioglioma, or demyelinating disease, may be challenging for the pathologist because specific markers are lacking. Recently, we described a strong EGFR...

Bipolar direct electrical stimulation (DES) of an awake patient is the reference technique for identifying brain structures to achieve maximal safe tumor resection. Unfortunately, DES cannot be performed in all cases. Alternative surgical tools are, therefore, needed to aid identification of subcortical connectivity during brain tumor removal....

International audience

Stem cell-like properties of Glioma initiating Cells (GiCs) fuel glioblastoma (GBM) development by providing the different cell types that comprise the tumor. It is therefore likely that the molecular circuitries that regulate their decision to self-renew or commit to a more differentiated state may offer targets for future innovative...

BACKGROUND: Diagnostic value of 3,4-dihydroxy-6-[(18)F]fluoro-L-phenylalanine ([(18)F]FDOPA) PET in patients with suspected recurrent gliomas is recognised. We conducted a multicentre prospective study to assess its added value in the practical management of patients suspected of recurrence of high grade gliomas (HGG). METHODS: Patients with a...

There is great interest in understanding how the cancer stem cell population may be maintained in solid tumors. Here we show that tumor cells exhibiting stem-like properties and expression of pluripotency markers NANOG and OCT4 can arise from original differentiated tumor cells freshly isolated from human glioblastomas and which have never...

Glioblastomas (GBs) are incurable brain tumors. The persistence of aggressive stem-like tumor cells after cytotoxic treatments compromises therapeutic efficacy, leading to GBM recurrence. Forcing the GBM cells to irreversibly abandon their aggressive stem-like phenotype may offer an alternative to conventional cytotoxic treatments. Here, we...