LEBRÓN ROMERO , José Antonio

En la presente Tesis Doctoral se han sintetizado cuatro metalosurfactantes derivados del Ru(bpy)3 2+, donde se han variado el número de cadenas hidrofóbicas y la longitud de las mismas. Se han caracterizado los tensioactivos y se ha estudiado su proceso de agregación. Posteriormente se ha investigado la interacción entre los monómeros y los...

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Este proyecto se basa en el uso del podcasting como herramienta de innovación docente, junto con la evaluación de los conocimientos adquiridos por el alumnado. Particularmente, se empleará la plataforma Spotify, donde se podrá reproducir, descargar y compartir audios de todo el contenido que se genere en la asignatura donde se implementará este...

La economía circular se está convirtiendo en uno de los conceptos más importantes en la economía mundial debido a los grandes beneficios medioambientales que presenta. No obstante, la falta de personal cualificado en esta área está provocando un gran rechazo en el sector industrial. Es por ello que la Universidad de Sevilla está incluyendo...

La situació actual ha generat la necessitat de replantejar- se l'ensenyament no presencial. No obstant aixo, aquest tipus d'ensenyament en carreres cientificotecniques pot tenir grans inconvenients. Per aquest motiu, en aquest treball es planteja una comparativa entre l'elaboració de practiques presencials i no presencials en assignatures...

A study of a dinitro-diester calix[4]arene (5,17-(3-nitrobenzylideneamino)-11,23-di-tert-butyl-25,27-diethoxycarbonyl methyleneoxy-26,28-dihydroxycalix[4]arene) interaction with calf-thymus DNA was carried out using several techniques. The measurements were done at various molar ratios X=[calixarene]/[DNA]. Results show diverse changes in the...

The interaction (adsorption process) of commercial ionic surfactants with non-functionalized and functionalized carbon nanotubes (CNTs) has been studied by potentiometric measurements based on the use of ion-selective electrodes. The goal of this work was to investigate the role of the CNTs' charge and structure in the CNT/surfactant...

Cefepime is an antibiotic with a broad spectrum of antimicrobial activity. However, this antibiotic has several side effects and a high degradation rate. For this reason, the preparation and characterization of new liposomes that are able to encapsulate this antibiotic seem to be an important research line in the pharmaceutical industry....

The interaction between calf-thymus DNA, ctDNA, and various single-chained surfactants with different functional groups at the end of hydrophobic tail was studied with the goal of investigating the influence of the functional group nature on surfactant DNA compacting efficiency. The surfactants investigated were dodecyltriethylammonium bromide...

The obtaining of nanocarriers of gene material and small drugs is still an interesting research line. Side-effects produced by the toxicity of several pharmaceutics, the high concentrations needed to get therapeutic effects, or their excessive use by patients have motivated the search for new nanostructures. For these reasons, cationic...

The research on flavonoids has exponentially grown since their first therapeutic evidence, in 1937. They are effective in vitro in a wide range of human diseases, particularly those mediated by free radicals, such as cancer, atherosclerosis, AIDS, or neuronal diseases. However, their applications have been reduced due to their low solubility,...

Gene therapy is a therapeutic process consisting of the transport of genetic material into cells. The design and preparation of novel carriers to transport DNA is an important research line in the medical field. Hybrid compounds such as metallo-liposomes, containing a mixture of lipids, were prepared and characterized. Cationic metal lipids...

The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. Four amphiphilic calixarenes were used. The length of the hydrophobic chains attached to the lower rim as well as the nature of the polar group present in the upper rim of the calixarenes were...

Vibriosis is one of the most usual infection diseases in bivalve mollusks, particularly affecting seeds and larvae, which are more susceptible than adults to these bacterial infections. The devastating effect of vibriosis in shellfish hatcheries is aggravated by the increasing resistance of many Vibrio species to traditional antibiotics,...

Gene therapy is a technique that is currently under expansion and development. Recent advances in genetic medicine have paved the way for a broader range of therapies and laid the groundwork for next-generation technologies. A terminally substituted difluorene-diester Schiff Base calix[4]arene has been studied in this work as possible...