MAZZUCA , Michel

Studies of molecular mecanisms involved in pain reveal major pain actors and lead to the development of future major therapeutic agents. Pain perception originates from ionic channel modulation. These channels are also responsible for the propagation of pain signals. In our study, we show that a specific ion channel modulates nociceptif signals...

INTRODUCTION: K(+) channels allow the passive and selective transport of K(+) ions through the membranes. They control K(+) homeostasis, neuronal and muscular excitabilities, and neurotransmitter and hormone release. EXEGESIS: K(+) channels are composed of pore-forming subunits associated with regulatory subunits. Many different K(+) channels...

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Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous...

Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous...

International audience