ROPERS , Delphine

Understanding the dynamical behavior of biological networks is complicated due to their large number of components and interactions. We present a simple method to analyse key processes for the system behavior, based on the a priori knowledge of the system trajectory and the simplification of mathematical models of these networks. The method...

Understanding the dynamical behavior of biological networks is complicated due to their large number of components and interactions. We present a method to analyse key processes for the system behavior, based on the a priori knowledge of the system trajectory and the simplification of mathematical models of these networks. The method consists...

Background: Understanding the dynamical behaviour of biological systems is challenged by their large number of components and interactions. While efforts have been made in this direction to reduce model complexity, they often prove insufficient to grasp which and when model processes play a crucial role. Answering these questions is fundamental...

The aim of this paper is to analyze the dynamical behavior of biological models of gene transcription and translation. We focus on a particular positive feedback loop governing the synthesis of RNA polymerase, needed for transcribing its own gene. We write a high-dimension model based on mass-action laws and reduce it to a two-variable model...

Different strains of a microorganism growing in the same environment display a wide variety of growth rates and growth yields. We developed a coarse-grained model to test the hypothesis that different resource allocation strategies, corresponding to different compositions of the proteome, can account for the observed rate-yield variability. The...

Microbial growth consists of the conversion of nutrients from the environment into biomassand small energy cofactors (ATP, NADH, NADPH, ...) driving biomass synthesis forward. Twomacroscopic criteria for characterizing microbial growth are growth rate and growth yield. Theformer refers to the rate of conversion of substrate into biomass, and...

Abstract Different strains of a microorganism growing in the same environment display a wide variety of growth rates and growth yields. We developed a coarse-grained model to test the hypothesis that different resource allocation strategies, corresponding to different compositions of the proteome, can account for the observed rate-yield...

Different strains of a microorganism growing in the same environment display a wide variety of growth rates and growth yields. We developed a coarse-grained model to test the hypothesis that different resource allocation strategies, corresponding to different compositions of the proteome, can account for the observed rate-yield variability. The...

The growth of microorganisms involves the conversion of nutrients in the environment into biomass, mostly proteins and other macromolecules. This conversion is accomplished by networks of biochemical reactions cutting across cellular functions, such as metabolism, gene expression, transport and signalling. Mathematical modelling is a powerful...